| Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction. | |
| | |
MedLine Citation:
|
PMID: 23122830 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the effect of obesity on the outcome of testicular sperm extraction (TESE) and assisted reproductive technology. DESIGN: Clinical retrospective study. SETTING: Center for reproductive medicine at a tertiary-care university hospital. PATIENT(S): Nine hundred seventy patients with nonobstructive azoospermia. INTERVENTION(S): Microdissection TESE followed by intracytoplasmic sperm injection (ICSI). MAIN OUTCOME MEASURE(S): Sperm retrieval rate and clinical pregnancy rate. RESULT(S): Testicular sperm were successfully retrieved in 55% of men overall. Of those with sperm found, clinical pregnancy rate was 51% and live birth rate 40%. Sperm retrieval rates were similar in men with body mass index (BMI) <25 kg/m(2), 25-30 kg/m(2), and >30 kg/m(2) (59%, 57%, and 54%, respectively). Mean BMI of men who contributed to pregnancy (27.3 ± 4.9 kg/m(2)) was lower than for men whose sperm did not contribute to a pregnancy (28.2 ± 5.4 kg/m(2)). No man with BMI >43 kg/m(2) (n = 11) contributed to a successful pregnancy, even though sperm were found in men with BMI up to 57 kg/m(2). On multivariable logistic regression analysis, male BMI was the only predictor of successful pregnancy among the variables analyzed, including male age, female age, and female BMI. CONCLUSION(S): Overweight men have lower clinical pregnancy rate after microdissection TESE and ICSI compared with men with normal BMI. Men with BMI >43 kg/m(2) did not contribute to any pregnancies, despite successful sperm retrieval. |
| | |
Authors:
|
Ranjith Ramasamy; Campbell Bryson; Jennifer E Reifsnyder; Queenie Neri; Gianpiero D Palermo; Peter N Schlegel |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-31 |
Journal Detail:
|
Title: Fertility and sterility Volume: - ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-11-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metformin decreases serum 8-hydroxy-2'-deoxyguanosine levels in polycystic ovary syndrome.
Next Document: Umbilical hernias and cirrhose.