Document Detail

Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction.
MedLine Citation:
PMID:  23122830     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of obesity on the outcome of testicular sperm extraction (TESE) and assisted reproductive technology.
DESIGN: Clinical retrospective study.
SETTING: Center for reproductive medicine at a tertiary-care university hospital.
PATIENT(S): Nine hundred seventy patients with nonobstructive azoospermia.
INTERVENTION(S): Microdissection TESE followed by intracytoplasmic sperm injection (ICSI).
MAIN OUTCOME MEASURE(S): Sperm retrieval rate and clinical pregnancy rate.
RESULT(S): Testicular sperm were successfully retrieved in 55% of men overall. Of those with sperm found, clinical pregnancy rate was 51% and live birth rate 40%. Sperm retrieval rates were similar in men with body mass index (BMI) <25 kg/m(2), 25-30 kg/m(2), and >30 kg/m(2) (59%, 57%, and 54%, respectively). Mean BMI of men who contributed to pregnancy (27.3 ± 4.9 kg/m(2)) was lower than for men whose sperm did not contribute to a pregnancy (28.2 ± 5.4 kg/m(2)). No man with BMI >43 kg/m(2) (n = 11) contributed to a successful pregnancy, even though sperm were found in men with BMI up to 57 kg/m(2). On multivariable logistic regression analysis, male BMI was the only predictor of successful pregnancy among the variables analyzed, including male age, female age, and female BMI.
CONCLUSION(S): Overweight men have lower clinical pregnancy rate after microdissection TESE and ICSI compared with men with normal BMI. Men with BMI >43 kg/m(2) did not contribute to any pregnancies, despite successful sperm retrieval.
Ranjith Ramasamy; Campbell Bryson; Jennifer E Reifsnyder; Queenie Neri; Gianpiero D Palermo; Peter N Schlegel
Publication Detail:
Type:  Journal Article     Date:  2012-10-31
Journal Detail:
Title:  Fertility and sterility     Volume:  99     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-04-04     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  372-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Azoospermia / epidemiology*,  therapy*
Body Mass Index
Microdissection / statistics & numerical data
New York
Overweight / epidemiology*
Pregnancy Outcome / epidemiology*
Pregnancy Rate*
Retrospective Studies
Risk Factors
Sperm Retrieval / statistics & numerical data*
Comment In:
J Urol. 2013 Sep;190(3):989   [PMID:  23931222 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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