Document Detail


Overweight and Obesity before, during and after Pregnancy: Part 1: Pathophysiology, Molecular Biology and Epigenetic Consequences.
MedLine Citation:
PMID:  25100878     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Overweight and obesity before conception as well as excessive weight gain during pregnancy are associated with endocrinological changes of mother and fetus. Insulin resistance physiologically increases during pregnancy, additional obesity further increases insulin resistance. In combination with reduced insulin secretion this leads to gestational diabetes which may develop into type-2-diabetes. The adipose tissue produces TNF-alpha, interleukins and leptin and upregulates these adipokines. Insulin resistance and obesity induce inflammatory processes and vascular dysfunction, which explains the increased rate of pregnancy-related hypertension and pre-eclampsia in obese pregnant women. Between 14 and 28 gestational weeks, the fetal adipose tissue is generated and the number of fat lobules is determined. Thereafter, an increase in adipose tissue is arranged by an enlargement of the lobules (hypertrophy), or even an increase in the number of fat cells (hyperplasia). Human and animal studies have shown that maternal obesity "programmes" the offspring for further obesity and chronic disease. Pregnant women, midwives, physicians and health care politicians should be better informed about prevention, pathophysiological mechanisms, and the burden for society caused by obesity before, during and after pregnancy.
Abstract available from the publisher.
Authors:
J H Stupin; B Arabin
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Geburtshilfe und Frauenheilkunde     Volume:  74     ISSN:  0016-5751     ISO Abbreviation:  Geburtshilfe Frauenheilkd     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-8-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370732     Medline TA:  Geburtshilfe Frauenheilkd     Country:  -    
Other Details:
Languages:  ENG     Pagination:  639-645     Citation Subset:  -    
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