Document Detail

Overview of treatment options for invasive fungal infections.
MedLine Citation:
PMID:  21366509     Owner:  NLM     Status:  MEDLINE    
The introduction of several new antifungals has significantly expanded both prophylaxis and treatment options for invasive fungal infections (IFIs). Relative to amphotericin B deoxycholate, lipid-based formulations of amphotericin B have significantly reduced the incidence of nephrotoxicity, but at a significant increase in drug acquisition cost. Newer, broad-spectrum triazoles (notably voriconazole and posaconazole) have added significantly to both the prevention and treatment of IFIs, most notably Aspergillus spp. (with voriconazole) and the treatment of some emerging fungal pathogens. Finally, a new class of parenteral antifungals, the echinocandins, is employed most frequently against invasive candidal infections. While the role of these newer agents continues to evolve, this review summarizes the activity, safety and clinical applications of agents most commonly employed in the treatment of IFIs.
Melanie W Pound; Mary L Townsend; Vincent Dimondi; Dustin Wilson; Richard H Drew
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-03-03
Journal Detail:
Title:  Medical mycology     Volume:  49     ISSN:  1460-2709     ISO Abbreviation:  Med. Mycol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-18     Completed Date:  2011-10-31     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  561-80     Citation Subset:  IM    
Copyright Information:
© 2011 ISHAM
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MeSH Terms
Antifungal Agents / adverse effects,  pharmacology,  therapeutic use*
Chemoprevention / methods
Mycoses / drug therapy*
Reg. No./Substance:
0/Antifungal Agents

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