Document Detail

Overview of some aspects of occurrence, formation and analysis of nitrosamines.
MedLine Citation:
PMID:  386508     Owner:  NLM     Status:  MEDLINE    
This review principally addresses a number of aspects of the occurrence and formation of the nitrosamines, highlighting principal areas of potential concern ranging from the spectrum of nitrosatable moieties found in the environment (e.g., secondary and tertiary amines, quaternary ammonium compounds, ureas, carbamates and guanidines), specific examples of nitrosamines found in food, alcoholic beverages, feed (and their significance for carcinogenesis bioassays), air and water. The factors influencing in vitro and in vivo nitrosation and the evidence for the latter in man are also discussed. Additionally, germane areas of the analysis of nitrosamines are reviewed with a focus on the major areas of concern and requirements of extreme sensitivity and selectivity in addition to the problems of artifacts in the analytical procedures.
L Fishbein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Science of the total environment     Volume:  13     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  157-88     Citation Subset:  IM    
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MeSH Terms
Air Pollution / analysis
Alcoholic Beverages / analysis
Animal Feed / analysis
Chemical Phenomena
Food Analysis
Neoplasms, Experimental / chemically induced
Nitrosamines* / adverse effects,  analysis,  metabolism
Water Pollution / analysis
Reg. No./Substance:
0/Carcinogens; 0/Nitrosamines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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