| Overview of resistant gram-positive pathogens in the surgical patient. | |
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MedLine Citation:
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PMID: 12594908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Staphylococci and enterococci are the most common pathogens in surgical-site and bloodstream infections. The emergence of drug resistance among these gram-positive bacteria thus poses a substantial threat to patients with surgical infections. Resistance to methicillin/oxacillin is frequently observed in Staphylococcus aureus isolates and is often accompanied by multidrug resistance. Vancomycin is usually the treatment of choice for infections caused by methicillin-resistant S. aureus (MRSA), so the recent appearance of S. aureus isolated with intermediate sensitivity to vancomycin is cause for concern. Vancomycin resistance has already appeared in most species of enterococci. Infections caused by vancomycin-resistant enterococci (VRE) are associated with increased mortality compared to infections caused by vancomycin-sensitive isolates. Measures for preventing vancomycin resistance include reducing the use of vancomycin and other agents that appear to be associated with VRE, including third-generation cephalosporins and anti-anaerobic drugs. Third-generation cephalosporins have also been implicated in the increased prevalence of MRSA infections. Prudent use of existing antibiotics is an essential strategy for combating the rising tide of drug-resistant gram-positive pathogens. |
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Authors:
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R P Rapp |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Surgical infections Volume: 1 ISSN: 1096-2964 ISO Abbreviation: Surg Infect (Larchmt) Publication Date: 2000 |
Date Detail:
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Created Date: 2003-02-21 Completed Date: 2003-04-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815642 Medline TA: Surg Infect (Larchmt) Country: United States |
Other Details:
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Languages: eng Pagination: 39-47 Citation Subset: IM |
Affiliation:
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Division of Pharmacy Practice and Science, University Hospital, University of Kentucky Medical School, Lexington, KY 40536-0082, USA. rprapp01@pop.uky.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cross Infection
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drug therapy*,
microbiology Drug Resistance, Bacterial* / genetics Enterococcus faecalis / drug effects Gram-Positive Bacteria / drug effects*, genetics Gram-Positive Bacterial Infections / drug therapy*, epidemiology Humans Infection Control Practice Guidelines as Topic Staphylococcus aureus / drug effects Surgical Procedures, Operative Surgical Wound Infection / drug therapy*, microbiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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