Document Detail

Overview of recent clinical trials in heart failure: what is the current standard of care?
MedLine Citation:
PMID:  11208254     Owner:  NLM     Status:  MEDLINE    
Heart failure develops as a consequence of cardiac injury. As the heart begins to fail to meet the body's metabolic demands, the renin angiotensin aldosterone system (RAAS) and the sympathetic nervous system are activated. These interrelated systems act in concert to facilitate cardiac output and tissue perfusion. Though these neurohormonal systems are initially compensatory, evidence suggests that they promote deleterious cardiac remodeling and myocyte destruction. Recent studies in patients with heart failure have targeted the RAAS and sympathetic nervous system for therapeutic intervention. This article reviews major recent multicenter, randomized, double-blind, and placebo-controlled trials in heart failure that have resulted in a new standard of care for patients with this devastating disease.
D R Murray; J Dugan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiology in review     Volume:  8     ISSN:  1061-5377     ISO Abbreviation:  Cardiol Rev     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-11-06     Completed Date:  2001-12-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  340-7     Citation Subset:  IM    
Department of Medicine/Cardiology (MC 7872), University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Aldosterone Antagonists / therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Cardiology / standards
Clinical Trials as Topic*
Drug Therapy, Combination
Follow-Up Studies
Guidelines as Topic*
Heart Failure / diagnosis,  drug therapy*,  mortality
Receptors, Angiotensin / antagonists & inhibitors*
Renin-Angiotensin System / physiology
Severity of Illness Index
Survival Analysis
Sympathetic Nervous System / physiology
Treatment Outcome
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Receptors, Angiotensin

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