| Overview of present day treatment of Parkinson's disease. | |
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MedLine Citation:
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PMID: 745015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the light of present day knowledge, augmenting striatal dopaminergic activity is the most effective means for controlling the symptoms of parkinsonism. This is best accomplished by the administration of levodopa with a peripheral decarboxylase inhibitor. However, limitations in its benefits develop after long-term administration in a substantial number of patients. In an attempt to overcome these a number of pharmacological agents acting on striatal dopaminergic mechanisms have undergone clinical trial. Of those tried Deprenyl, an MAO-B inhibitor, given with levodopa and carbidopa has shown the most promise. Preliminary results in 35 patients indicate that it is useful in diminishing the incidence of "on-off" phenomena--one of the most limiting reactions to levodopa--as well as enabling some patients to recoup their loss of therapeutic benefits. Though far from resolving all of the therapeutic difficulties encountered with prolonged use of levodopa, it appears to be a valuable adjunctive agent for the long-term problem patient. |
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Authors:
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M D Yahr |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neural transmission Volume: 43 ISSN: 0300-9564 ISO Abbreviation: J. Neural Transm. Publication Date: 1978 |
Date Detail:
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Created Date: 1979-05-23 Completed Date: 1979-05-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0337042 Medline TA: J Neural Transm Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 227-38 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bromocriptine / pharmacology Dose-Response Relationship, Drug Drug Therapy, Combination Female Humans Levodopa / blood, therapeutic use* Male Middle Aged Parkinson Disease / drug therapy* Phenethylamines / therapeutic use* Receptors, Dopamine / drug effects Selegiline / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Levodopa; 0/Phenethylamines; 0/Receptors, Dopamine; 14611-51-9/Selegiline; 25614-03-3/Bromocriptine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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