Document Detail


Overview of pathogenesis of systemic sclerosis.
MedLine Citation:
PMID:  19487220     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aetiology of SSc is subject to ongoing research, as the precise events that underlie the development of this disease remain unclear. The pathogenesis is known to involve endothelium, epithelium, fibroblasts, innate and adaptive immune systems and their component immunological mediators. Endothelial cell damage may be the initiating factor, but the precise triggering event(s) remain elusive. Angiogenesis also appears to be dysregulated. Vasculopathy shows similarities in different organs (e.g. pulmonary arterial hypertension, renal disease, digital tip ulcers). Endothelin-1 is a potent mediator of vasculopathy, and hence represents a highly relevant target for intervention of vascular features in SSc.
Authors:
D J Abraham; T Krieg; J Distler; O Distler
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  48 Suppl 3     ISSN:  1462-0332     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  iii3-7     Citation Subset:  AIM; IM    
Affiliation:
Centre for Rheumatology and Connective Tissue Disease, Royal Free and University College Medical School, University College London, Hampstead, London, UK. d.abraham@medsch.ucl.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Endothelium, Vascular / immunology,  pathology
Epithelium / immunology,  pathology
Fibroblasts / immunology,  pathology
Humans
Lung / immunology,  pathology
Scleroderma, Systemic / etiology*,  immunology
Skin / immunology,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosis.
Next Document:  Renal complications and scleroderma renal crisis.