Document Detail

Overview of observational studies of low-dose helical computed tomography screening for lung cancer.
MedLine Citation:
PMID:  15691245     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Lung cancer is a substantial public health problem in Western countries. Evidence from previous controlled trials of chest radiography and sputum cytology does not support lung cancer screening, but computed tomography (CT) screening has recently emerged as a more sensitive screening tool. For the present article, the available observational studies of low-dose helical CT screening for lung cancer were reviewed. METHODOLOGY: An evidence-based review of all published observational studies of low-dose helical CT screening for lung cancer, identified by an extensive search of Medline, was conducted. RESULTS: Eight observational studies of CT screening for lung cancer were identified. Relative to chest radiography, low-dose helical CT is a sensitive screening tool and can detect a high proportion of small lung cancers at an early and resectable stage. The yield of sputum cytology in addition to CT screening appears to be relatively low. To date, 5-year lung cancer survival of all individuals participating in baseline screening has not been reported for any of the studies. CONCLUSIONS: Although these preliminary studies are very promising, it remains to be proven that the early detection and treatment of lung cancer will lead to a reduction in mortality. This issue will be addressed by randomized controlled trials. In the interim, the long-term follow up of these observational studies could provide further insights.
Renee L Manser; Louis B Irving; Margaret P de Campo; Michael J Abramson; Christine A Stone; Karen E Pedersen; Mark Elwood; Donald A Campbell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  10     ISSN:  1323-7799     ISO Abbreviation:  Respirology     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-04     Completed Date:  2005-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  IM    
Clinical Epidemiology and Health Service Evaluation Unit, Royal Melbourne Hospital, Victoria, Australia.
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MeSH Terms
Lung Neoplasms / prevention & control*,  radiography
Mass Screening*
Neoplasm Staging
Radiation Dosage
Radiography, Thoracic
Sputum / cytology
Survival Rate
Tomography, Spiral Computed / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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