Document Detail

Overview of marrow transplantation.
MedLine Citation:
PMID:  3911595     Owner:  NLM     Status:  MEDLINE    
Bone marrow transplantation is now an accepted form of therapy for many hematologic disorders including aplastic anemia, genetically determined diseases and malignant diseases, particularly leukemia, and for rescue of patients given intensive chemoradiotherapy for malignant disease. The donor may be a healthy identical twin, a family member or even an unrelated person. Selection is made on the basis of human leukocyte antigen tissue typing. Intensive chemoradiotherapy is used to suppress patients' immune systems to facilitate engraftment and destroy diseased marrow. Transfusion of platelets, erythrocytes and granulocytes (or all of these), antibiotic coverage and protection from infection are necessary during the pancytopenic period. Use of a Hickman catheter facilitates maintenance of adequate nutritional intake and provides easy access for drawing blood and intravenous administration. Survival rates vary considerably depending on a patient's disease, clinical state and age. Patients with aplastic anemia transplanted early in the course of their disease have a survival rate of approximately 80%. Patients with acute lymphoblastic leukemia are usually transplanted in a second or subsequent remission and have a survival rate of 25% to 40%. Patients with acute nonlymphoblastic leukemia in remission have survivals ranging from 45% to 70%. More than 200 patients in the chronic phase of chronic granulocytic leukemia have been transplanted with survival ranging from 50% to 70%. Complications of marrow transplantation include marrow graft rejection, graft-versus-host disease, immunologic insufficiency and the possibility of recurrence of the leukemia. The risk of death from these complications must be balanced against the possibility of cure.
E D Thomas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Western journal of medicine     Volume:  143     ISSN:  0093-0415     ISO Abbreviation:  West. J. Med.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-03-04     Completed Date:  1986-03-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0410504     Medline TA:  West J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  834-7     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Anemia, Aplastic / therapy
Bone Marrow Transplantation*
Ethics, Medical
Graft Rejection
Graft vs Host Disease / immunology
Leukemia / therapy
Leukemia, Myeloid / therapy
Neoplasm Recurrence, Local
Preoperative Care

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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