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Overview of investigations into pulmonary hemorrhage among infants in Cleveland, Ohio.
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MedLine Citation:
PMID:  10346998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Idiopathic pulmonary hemorrhage was diagnosed in 37 infants in the Cleveland, Ohio, area between 1993 and 1998. This rare disorder has been related to 12 deaths, including 7 originally thought to be sudden infant death syndrome. Thirty of the infants were African American, all of whom lived in a limited geographic area of eastern metropolitan Cleveland, an area of older housing stock. An investigation led by the Centers for Disease Control and Prevention has found an association with household exposure to a toxigenic mold, Stachybotrys chartarum, and other fungi. The rapidly growing lungs of young infants appear to be especially vulnerable to the toxins made by toxigenic molds. Environmental tobacco smoke was frequently present in the infants' homes and may be a trigger precipitating the acute bleeding. Stachybotrys, although not thought to be a common mold, is known to have a wide geographic distribution. An additional 101 cases of acute, idiopathic pulmonary hemorrhage have been reported in infants in the United States over the past 5 years. In this overview, the investigations are summarized, the clinical profile is described, the toxicity of S. chartarum is discussed, and pathophysiologic concepts are presented.
Authors:
D G Dearborn; I Yike; W G Sorenson; M J Miller; R A Etzel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  107 Suppl 3     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  2000-08-29     Completed Date:  2000-08-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  495-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106-5000, USA. dxd9@po.cwru.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Environmental Microbiology
Hemorrhage / epidemiology,  etiology*,  physiopathology
Hemosiderosis / epidemiology,  etiology,  physiopathology
Humans
Infant
Lung Diseases / epidemiology,  etiology*,  physiopathology
Mice
Ohio / epidemiology
Stachybotrys / isolation & purification,  pathogenicity
Grant Support
ID/Acronym/Agency:
ES08549/ES/NIEHS NIH HHS; M01 RR 00080/RR/NCRR NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 6 Year: 1999
Volume: 107 Issue: Suppl 3
First Page: 495 Last Page: 499
ID: 1566217
PubMed Id: 10346998
Publisher Item Identifier: sc271_5_1835

Overview of investigations into pulmonary hemorrhage among infants in Cleveland, Ohio.
D G Dearborn
I Yike
W G Sorenson
M J Miller
R A Etzel
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106-5000, USA. dxd9@po.cwru.edu



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