Document Detail

Overview of intracoronary thrombolysis.
MedLine Citation:
PMID:  10158385     Owner:  NLM     Status:  MEDLINE    
Despite these negative results, the theoretical benefit of lysing clot in acute coronary syndromes remains appealing. Whether the use of more potent antiplatelet agents or antithrombin agents might improve the results of thrombolytics in unstable angina and acute myocardial infarction without an unacceptable bleeding risk remains speculative. Site-specific lysis with a high local concentration of thrombolytic without systemic fibrinolysis has the appeal of potentially fewer bleeding complications, but the safety and efficacy of site-specific thrombolysis remains unclear. Early results with coronary stenting to maintain the largest lumen possible in combination with lytic agents in acute infarction appears favorable in a preliminary report. It is possible that reocclusion mediated by coronary obstruction with static flow cannot be salvaged with lytics alone, but the adjunctive use of stents or other interventions to decrease mechanical atherosclerotic obstruction may be beneficial in the future. However, planned and ongoing trials will be required before a beneficial role for adjunctive thrombolysis with angioplasty in acute ischemic syndromes can be established.
P L Whitlow
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  7 Suppl E     ISSN:  1042-3931     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  1995  
Date Detail:
Created Date:  1996-07-30     Completed Date:  1996-07-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2E-9E     Citation Subset:  T    
Department of Cardiology, Cleveland Clinic Foundation, Ohio, USA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Combined Modality Therapy
Coronary Artery Bypass
Coronary Disease / drug therapy*
Fibrinolytic Agents / adverse effects,  therapeutic use*
Graft Occlusion, Vascular / drug therapy
Myocardial Infarction / drug therapy*
Thrombolytic Therapy*
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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