| Overview: hypertension and atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 3293398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Many large-scale trials of drug treatment for hypertension have shown an apparent lack of benefit with regard to the incidence of complications related to atherosclerosis. Recent experimental evidence has contributed to an understanding of the pathogenesis of hypertensive vascular disease, although exact mechanisms by which hypertension and antihypertensive drugs influence the atherosclerotic process are still poorly defined. In animal models, hypertension appears to induce a sequence of changes in endothelial cells, smooth muscle cells, and endothelial permeability. However, increased lipid deposition in the intima and acceleration of atherosclerosis appear to require elevation of plasma lipid levels. Some beta-blockers have been found to retard the development of atherosclerosis in the cholesterol-fed rabbit model. The clinical applicability of these interesting research findings awaits further investigation. |
| | |
Authors:
|
A Chobanian |
Related Documents
:
|
20540708 - Sulfur dioxide: a novel gaseous signal in the regulation of cardiovascular functions. 10774458 - Atherogenic lipids and endothelial dysfunction: mechanisms in the genesis of ischemic s... 20100288 - Possibility of the regression of atherosclerosis through the prevention of endothelial ... 17178598 - Endothelial cells and macrophages, partners in atherosclerotic plaque progression. 12241528 - Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor ... 19754268 - Endothelin-1 impairs nitric oxide signaling in endothelial cells through a protein kina... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: American heart journal Volume: 116 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1988 Jul |
Date Detail:
|
Created Date: 1988-08-12 Completed Date: 1988-08-12 Revised Date: 2006-02-27 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 319-22 Citation Subset: AIM; IM |
Affiliation:
|
Cardiovascular Institute, Boston University School of Medicine, MA 02118. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antihypertensive Agents / therapeutic use Arteriosclerosis / blood, etiology*, prevention & control Blood Pressure / drug effects Disease Models, Animal Humans Hypertension / blood, complications*, drug therapy Lipids / blood Lipoproteins / blood |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Lipids; 0/Lipoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Safety After Fifty Evaluation trial: evaluation of the safety and efficacy of antihypertensive t...
Next Document: Thromboatherosclerotic complications in hypertensives: results of the Stockholm Metoprolol (secondar...