Document Detail

Overview on atherosclerotic systolic hypertension.
MedLine Citation:
PMID:  3301695     Owner:  NLM     Status:  MEDLINE    
Hypertension in older atherosclerotic patients is characterised by a disproportionate elevation of systolic and pulse pressure contrasting with a subnormal diastolic level. Increased systolic pressure is strongly related to the excess of cerebrovascular complications and congestive heart failure observed in these patients. The physiopathological pattern is marked by a strong reduction in compliance of large arteries directly responsible for the predominant high systolic pressure because of the impairment of the buffering function of the arteries on the cardiac pulse wave. Clinical management is directed to the elevation of athero-arteriosclerotic changes of large arteries by means of appropriate non-invasive ultrasonic techniques and specific lowering in systolic pressure. Antihypertensive treatment must specifically decrease systolic pressure without superimposing adverse effects on the generalized and focalized atherosclerotic process. In this respect, new pharmacological agents capable of direct actions on large arteries might be suitable.
A Simon; J Levenson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of cardiology     Volume:  16     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-18     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / therapeutic use
Arteriosclerosis / complications*,  diagnosis,  physiopathology
Hypertension / etiology*,  therapy
Middle Aged
Reg. No./Substance:
0/Antihypertensive Agents

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