Document Detail

Overview of therapeutic ultrasound applications and safety considerations.
MedLine Citation:
PMID:  22441920     Owner:  NLM     Status:  MEDLINE    
Applications of ultrasound in medicine for therapeutic purposes have been accepted and beneficial uses of ultrasonic biological effects for many years. Low-power ultrasound of about 1 MHz has been widely applied since the 1950s for physical therapy in conditions such as tendinitis and bursitis. In the 1980s, high-pressure-amplitude shock waves came into use for mechanically resolving kidney stones, and "lithotripsy" rapidly replaced surgery as the most frequent treatment choice. The use of ultrasonic energy for therapy continues to expand, and approved applications now include uterine fibroid ablation, cataract removal (phacoemulsification), surgical tissue cutting and hemostasis, transdermal drug delivery, and bone fracture healing, among others. Undesirable bioeffects can occur, including burns from thermal-based therapies and severe hemorrhage from mechanical-based therapies (eg, lithotripsy). In all of these therapeutic applications of ultrasound bioeffects, standardization, ultrasound dosimetry, benefits assurance, and side-effect risk minimization must be carefully considered to ensure an optimal benefit to risk ratio for the patient. Therapeutic ultrasound typically has well-defined benefits and risks and therefore presents a manageable safety problem to the clinician. However, safety information can be scattered, confusing, or subject to commercial conflicts of interest. Of paramount importance for managing this problem is the communication of practical safety information by authoritative groups, such as the American Institute of Ultrasound in Medicine, to the medical ultrasound community. In this overview, the Bioeffects Committee of the American Institute of Ultrasound in Medicine outlines the wide range of therapeutic ultrasound methods, which are in clinical use or under study, and provides general guidance for ensuring therapeutic ultrasound safety.
Douglas L Miller; Nadine B Smith; Michael R Bailey; Gregory J Czarnota; Kullervo Hynynen; Inder Raj S Makin;
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  31     ISSN:  1550-9613     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-23     Completed Date:  2012-08-02     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  623-34     Citation Subset:  IM    
Department of Radiology, University of Michigan, 3240A Medical Science Building I, 1301 Catherine St, Ann Arbor, MI 48109-5667, USA.
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MeSH Terms
Lithotripsy / adverse effects*,  methods*,  trends
Ultrasonic Therapy / adverse effects*,  methods*
Grant Support
Timothy Bigelow / ; Gregory Czarnota / ; Jacques Abramowicz / ; Michael Bailey / ; Andrew Brayman / ; Charles Church / ; Cheri Deng / ; Kullervo Hynynen / ; Kolios / ; Inder Makin / ; Thomas Nelson / ; Michael Oelze / ; Jean Lea Spitz / ; Marvin Ziskin / ; John Abbott / ; Lori Barr / ; Stephen Bly / ; Paul Carson / ; Edwin Carstensen / ; Floyd Dunn / ; Peter Edmonds / ; Gerald Harris / ; Christy Holland / ; Christopher Merritt / ; Douglas Miller / ; Wesley Nyborg / ; Narendra Sanghvi / ; Thomas Szabo / ; Jinxing Tan / ; Kai Thomenius / ; Jennifer Bagley / ; Stanley Barnett / ; Samuel Nagle / ; Gail ter Haar / ; Shahram Vaezy / ; J Brian Fowlkes / ; Dev Maulik /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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