Document Detail

An overview of glycemic control in the coronary care unit with recommendations for clinical management.
MedLine Citation:
PMID:  20144388     Owner:  NLM     Status:  MEDLINE    
The observation that elevated glucose occurs frequently in the setting of acute myocardial infarction was made decades ago. Since then numerous studies have documented that hyperglycemia is a powerful risk factor for increased mortality and in-hospital complications in patients with acute coronary syndromes. While some questions in this field have been answered in prior investigations, many critical gaps in knowledge continue to exist and remain subjects of intense debate. This review summarizes what is known about the relationship between hyperglycemia, glucose control, and outcomes in critically ill patients with acute coronary syndromes, addresses the gaps in knowledge and controversies, and offers general recommendations regarding glucose management in the coronary care unit.
Mikhail Kosiborod; Prakash Deedwania
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-11-01
Journal Detail:
Title:  Journal of diabetes science and technology     Volume:  3     ISSN:  1932-2968     ISO Abbreviation:  J Diabetes Sci Technol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-09-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101306166     Medline TA:  J Diabetes Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1342-51     Citation Subset:  IM    
Mid America Heart Institute of Saint Luke's Hospital, Kansas City, Missouri 64111, USA.
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MeSH Terms
Acute Coronary Syndrome / blood,  complications*,  drug therapy,  mortality
Blood Glucose / drug effects*,  metabolism
Coronary Care Units*
Critical Illness
Evidence-Based Medicine
Hyperglycemia / blood,  diagnosis,  drug therapy*,  etiology,  mortality
Hypoglycemia / blood,  chemically induced,  diagnosis
Hypoglycemic Agents / administration & dosage*,  adverse effects
Insulin / administration & dosage*,  adverse effects
Physician's Practice Patterns
Practice Guidelines as Topic
Risk Assessment
Risk Factors
Treatment Outcome
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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