| Overview of the development of personalized genomic medicine and surgery. | |
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MedLine Citation:
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PMID: 21424870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Personalized genomic medicine and surgery (PGMS) represents a new approach to health care that customizes patients' medical treatment according to their own genetic information. This new approach is the result of increased knowledge of the human genome and ways this information can be applied by physicians in the medical and surgical management of their patients. A patient's genotype can yield important information concerning disease susceptibility and the effectiveness of medications, therefore guiding specific, targeted imaging and treatment therapies. This review summarizes major achievements of human genomic studies and applications of genomics in health care. Five years ago we developed a model for the development of PGMS in which genomic profile guides choice of therapy. In this article we discussed our progress, including an updating of the model, and a future vision of PGMS. |
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Authors:
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F Charles Brunicardi; Richard A Gibbs; David A Wheeler; John Nemunaitis; William Fisher; John Goss; Changyi Chen |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: World journal of surgery Volume: 35 ISSN: 1432-2323 ISO Abbreviation: World J Surg Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-06-30 Completed Date: 2011-12-22 Revised Date: 2012-02-20 |
Medline Journal Info:
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Nlm Unique ID: 7704052 Medline TA: World J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1693-9 Citation Subset: IM |
Affiliation:
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Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden Street, Suite 1500, Houston, TX 77030, USA. cbrunica@bcm.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Genetic Testing
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methods Genomics / methods* Human Genome Project Humans Individualized Medicine / methods* Molecular Targeted Therapy / methods Pharmacogenetics / methods Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA095731-06A1/CA/NCI NIH HHS; R01 DK046441-13/DK/NIDDK NIH HHS; R01-CA095731/CA/NCI NIH HHS; R01-DK46441/DK/NIDDK NIH HHS; U54 HG003273-03/HG/NHGRI NIH HHS; U54 HG004973-01/HG/NHGRI NIH HHS; U54-HG003273/HG/NHGRI NIH HHS; U54-HG004973/HG/NHGRI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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