Document Detail


Oversynthesis of Riboflavin in the Yeast Pichia guilliermondii is Accompanied by Reduced Catalase and Superoxide Dismutases Activities.
MedLine Citation:
PMID:  23053489     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Iron deficiency causes oversynthesis of riboflavin in several yeast species, known as flavinogenic yeasts. Under iron deprivation conditions, Pichia guilliermondii cells increase production of riboflavin and malondialdehyde and the formation of protein carbonyl groups, which reflect increased intracellular content of reactive oxygen species. In this study, we found that P. guilliermondii iron deprived cells showed dramatically decreased catalase and superoxide dismutase activities. Previously reported mutations rib80, rib81, and hit1, which affect repression of riboflavin synthesis and iron accumulation by iron ions, caused similar drops in activities of the mentioned enzymes. These findings could explain the previously described development of oxidative stress in iron deprived or mutated P. guilliermondii cells that overproduce riboflavin. Similar decrease in superoxide dismutase activities was observed in iron deprived cells in the non-flavinogenic yeast Saccharomyces cerevisiae.
Authors:
Tetyana M Prokopiv; Dariya V Fedorovych; Yuriy R Boretsky; Andriy A Sibirny
Related Documents :
19935869 - Beyond structure, to survival: activation of stat3 by cadherin engagement.
23329319 - Antibacterial and antibiofilm effects of iron chelators against prevotella intermedia.
20934869 - Approaching the molecular origins of collective dynamics in oscillating cell populations.
2019739 - Analysis of lymphocyte shape by visual classification, calculated measures of shape or ...
18368529 - Purinergic signaling microenvironments: an introduction.
18674929 - An overview of animal cell substrates for biological products.
25110009 - Intracellular redistribution of acetyl-coa, the pivotal point in differential susceptib...
22972029 - Tauroursodeoxycholate, a chemical chaperone, prevents palmitate-induced apoptosis in pa...
11820619 - Significance of cell adhesion molecules, cd56/ncam in particular, in human tumor growth...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-9
Journal Detail:
Title:  Current microbiology     Volume:  -     ISSN:  1432-0991     ISO Abbreviation:  Curr. Microbiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7808448     Medline TA:  Curr Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Analytical Biotechnology, Institute of Cell Biology NAS of Ukraine, Drahomanov Str. 14/16, Lviv, 79005, Ukraine.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Optimal Use of MRSASelect and PCR to Maximize Sensitivity and Specificity of MRSA Detection.
Next Document:  Diversity of Chemotactic Heterotrophic Bacteria Associated with Arctic Cyanobacteria.