| Oversynthesis of Riboflavin in the Yeast Pichia guilliermondii is Accompanied by Reduced Catalase and Superoxide Dismutases Activities. | |
| | |
MedLine Citation:
|
PMID: 23053489 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Iron deficiency causes oversynthesis of riboflavin in several yeast species, known as flavinogenic yeasts. Under iron deprivation conditions, Pichia guilliermondii cells increase production of riboflavin and malondialdehyde and the formation of protein carbonyl groups, which reflect increased intracellular content of reactive oxygen species. In this study, we found that P. guilliermondii iron deprived cells showed dramatically decreased catalase and superoxide dismutase activities. Previously reported mutations rib80, rib81, and hit1, which affect repression of riboflavin synthesis and iron accumulation by iron ions, caused similar drops in activities of the mentioned enzymes. These findings could explain the previously described development of oxidative stress in iron deprived or mutated P. guilliermondii cells that overproduce riboflavin. Similar decrease in superoxide dismutase activities was observed in iron deprived cells in the non-flavinogenic yeast Saccharomyces cerevisiae. |
| | |
Authors:
|
Tetyana M Prokopiv; Dariya V Fedorovych; Yuriy R Boretsky; Andriy A Sibirny |
Related Documents
:
|
19935869 - Beyond structure, to survival: activation of stat3 by cadherin engagement. 23329319 - Antibacterial and antibiofilm effects of iron chelators against prevotella intermedia. 20934869 - Approaching the molecular origins of collective dynamics in oscillating cell populations. 2019739 - Analysis of lymphocyte shape by visual classification, calculated measures of shape or ... 18368529 - Purinergic signaling microenvironments: an introduction. 18674929 - An overview of animal cell substrates for biological products. 22972029 - Tauroursodeoxycholate, a chemical chaperone, prevents palmitate-induced apoptosis in pa... 11820619 - Significance of cell adhesion molecules, cd56/ncam in particular, in human tumor growth... 1257749 - Marine oscillatoria (trichodesmium): explanation for aerobic nitrogen fixation without ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-9 |
Journal Detail:
|
Title: Current microbiology Volume: - ISSN: 1432-0991 ISO Abbreviation: Curr. Microbiol. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7808448 Medline TA: Curr Microbiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Analytical Biotechnology, Institute of Cell Biology NAS of Ukraine, Drahomanov Str. 14/16, Lviv, 79005, Ukraine. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Optimal Use of MRSASelect and PCR to Maximize Sensitivity and Specificity of MRSA Detection.
Next Document: Diversity of Chemotactic Heterotrophic Bacteria Associated with Arctic Cyanobacteria.