Document Detail

Oversizing and Restenosis with Self-Expanding Stents in Iliofemoral Arteries.
MedLine Citation:
PMID:  22006026     Owner:  NLM     Status:  Publisher    
PURPOSE: Uncoated self-expanding nitinol stents (NS) are commonly oversized in peripheral arteries. In current practice, 1-mm oversizing is recommended. Yet, oversizing of NS may be associated with increased restenosis. To provide further evidence, NS were implanted in porcine iliofemoral arteries with a stent-to-artery-ratio between 1.0 and 2.3. Besides conventional uncoated NS, a novel self-expanding NS with an antiproliferative titanium-nitride-oxide (TiNOX) coating was tested for safety and efficacy. METHODS: Ten uncoated NS and six TiNOX-coated NS (5-6 mm) were implanted randomly in the iliofemoral artery of six mini-pigs. After implantation, quantitative angiography (QA) was performed for calculation of artery and minimal luminal diameter. Follow-up was performed by QA and histomorphometry after 5 months. RESULTS: Stent migration, stent fracture, or thrombus formation were not observed. All stents were patent at follow-up. Based on the location of the stent (iliac/femoral) and the stent-to-artery-ratio, stent segments were divided into "normal-sized" (stent-to-artery-ratio < 1.4, n = 12) and "oversized" (stent-to-artery-ratio ≥ 1.4, n = 9). All stent segments expanded to their near nominal diameter during follow-up. Normal-sized stent segments increased their diameter by 6% and oversized segments by 29%. A significant correlation between oversizing and restenosis by both angiography and histomorphometry was observed. Restenosis rates were similar for uncoated NS and TiNOX-coated NS. CONCLUSIONS: TiNOX-coated NS are as safe and effective as uncoated NS in the porcine iliofemoral artery. All stents further expand to near their nominal diameter during follow-up. Oversizing is linearly and positively correlated with neointimal proliferation and restenosis, which may not be reduced by TiNOX-coating.
Ardan M Saguner; Tobias Traupe; Lorenz Räber; Nina Hess; Yara Banz; Arhan R Saguner; Nicolas Diehm; Otto M Hess
Related Documents :
25224296 - Double bifurcation optimization stent system technique for left main stenosis.
16376206 - Can phlebectomy be deferred in the treatment of varicose veins?
21811396 - Multiple retinal emboli following a new carotid stenting procedure.
25298846 - Ascending to abdominal aorta extraanatomic bypass for descending aortic coarctation: a ...
18159356 - Gemella species endocarditis in a child.
22318446 - Endovascular treatment of infrarenal abdominal aortic lesions with or without common il...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-18
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  -     ISSN:  1432-086X     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Swiss Cardiovascular Center, University Hospital, Bern, Switzerland,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Renal artery revascularization after unsuccessful percutaneous therapy: a single centre experience.
Next Document:  A Surgeon's View on Endarterectomy and Stenting in 2011: Lest We Forget, It's All About Preventing S...