Document Detail

Overshoot phenomena of respiratory gas variables during exercise recovery in cardiac patients.
MedLine Citation:
PMID:  22322878     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Transient increases (overshoot) in respiratory gas variables have been observed during exercise recovery, but their clinical significance is not clearly understood. Our group evaluated the relationship between the presence of overshoot of respiratory gas variables and the parameters obtained from cardiopulmonary exercise testing (CPX).
METHODS AND RESULTS: In total, 227 patients with various cardiac diseases underwent CPX. The overshoot phenomena of O₂ uptake (·VO₂), ·VO₂/heart rate (O₂-pulse), and CO₂ output (·VCO₂) were analyzed by respiratory gas analysis during recovery after maximal exercise. The overshoot of ·VO₂, O₂-pulse, and ·VCO₂ were recognized in 11 (5%), 43 (19%), and 12 (5%) patients, respectively. Compared with the patients without a ·VO₂ overshoot, those with a ·VO₂ overshoot had a significantly lower peak ·VO₂ (12.3±3.7 vs. 17.9±6.2ml·min⁻¹·kg⁻¹, P=0.003), lower anaerobic threshold (9.4±1.7 vs. 12.4±3.3 ml·min⁻¹·kg⁻¹, P=0.001), higher ·VE-·VCO₂ slope (38.0±5.2 vs. 33.2±9.6, P=0.013), and lower left ventricular ejection fraction (LVEF) (39.9±22.8 vs. 55.8±16.8%, P=0.003). Similar findings were obtained for the patients with an O₂-pulse overshoot and those with a ·VCO₂ overshoot.
CONCLUSIONS: The overshoot phenomena of respiratory gas variables during recovery after maximal exercise are correlated with impaired cardiopulmonary function during exercise in cardiac patients.
Takeya Suzuki; Akira Koike; Osamu Nagayama; Koji Sakurada; Hidekazu Tsuneoka; Jo Kato; Takeshi Yamashita; Junichi Yamazaki
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Publication Detail:
Type:  Journal Article     Date:  2012-02-09
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  76     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-27     Completed Date:  2012-06-25     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  876-83     Citation Subset:  IM    
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MeSH Terms
Anaerobic Threshold
Blood Pressure
Breath Tests
Carbon Dioxide / metabolism*
Exercise Test
Exercise Tolerance
Heart Diseases / diagnosis,  metabolism,  physiopathology*
Heart Rate
Middle Aged
Oxygen / metabolism*
Oxygen Consumption*
Recovery of Function
Stroke Volume
Time Factors
Ventricular Function, Left
Reg. No./Substance:
142M471B3J/Carbon Dioxide; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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