Document Detail


Overrepresentation of the short arm of chromosome 12 in seminoma and nonseminoma groups of testicular germ cell tumors.
MedLine Citation:
PMID:  12034520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The amplification of the short arm of the chromosome 12, especially as the i(12p) marker chromosome, has been found to be a highly nonrandom chromosome abnormality associated with testicular germ cell tumors (TGCT). A series of adult TGCT consisting of seven seminomas (SE) and eight nonseminomas (NS) was analyzed by conventional cytogenetics and fluorescent in situ hybridization. Multiplied chromosome 12 material originating from typical i(12p) and from other markers carrying chromosome 12-derived material was found in almost all analyzed tumors (6 of 7 SE cases and 8 of 8 NS cases). Heterogeneity in the copy number of i(12p) and other 12p-derived markers, as well as chromosome 12 aneuploidy, were higher in NS tumors than in SE.
Authors:
Barbara Pienkowska-Grela; Beata Grygalewicz; Urszula Bregula
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  134     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-29     Completed Date:  2002-06-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  102-8     Citation Subset:  IM    
Affiliation:
Cytogenetic Laboratory, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 5 K.W. Roentgen Str, 02-781, Warsaw, Poland. barpien@coi.waw.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Chromosome Aberrations
Chromosome Banding
Chromosomes, Human, Pair 12 / genetics*
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Seminoma / genetics*
Testicular Neoplasms / genetics*
Tumor Cells, Cultured

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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