Document Detail

Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks.
MedLine Citation:
PMID:  15465594     Owner:  NLM     Status:  MEDLINE    
Corticotropin-releasing hormone (CRH) is a central mediator in the response to stress, coordinating behavioral, autonomic and neuroendocrine activation. CRH overproduction is implicated in several affective disorders, including major depression, panic-anxiety disorder and anorexia--diseases also associated with altered immune function. We investigated the link between CRH overdrive and immune function using CRH transgenic mice. Following immunization, CRH transgenic mice fail to form germinal centers; chronic glucocorticoid administration recapitulates this effect in wild-type mice. Regulation of germinal centers by glucocorticoids appears to be mediated, in part, through effects on follicular dendritic cells (FDC), providing a novel mechanism by which CRH dysregulation may significantly impair humoral immune responses.
Susan E Murray; Holly L Rosenzweig; Martha Johnson; Mark O Huising; Kristine Sawicki; Mary P Stenzel-Poore
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  156     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2004-11-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  31-41     Citation Subset:  IM    
Department of Molecular Microbiology and Immunology, Mail Code L220, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97201, USA.
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MeSH Terms
Cell Differentiation / immunology
Corticosterone / pharmacology,  physiology*
Corticotropin-Releasing Hormone / biosynthesis*,  physiology*
Dendritic Cells, Follicular / drug effects,  immunology*,  metabolism
Dose-Response Relationship, Drug
Germinal Center / drug effects,  immunology,  pathology*
Mice, Inbred C57BL
Mice, Transgenic
Grant Support
Reg. No./Substance:
50-22-6/Corticosterone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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