| Overoxidized polypyrrole/multi-walled carbon nanotubes composite modified electrode for in vivo liquid chromatography-electrochemical detection of dopamine. | |
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MedLine Citation:
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PMID: 19473890 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Overoxidized polypyrrole/multi-walled carbon nanotubes (OPPy/MWNTs) modified electrode has been developed for sensitively detecting dopamine (DA). OPPy films developed outside MWNTs might have a porous morphology. Thus, OPPy/MWNTs films developed by this method do not reject ascorbic acid (AA). However, OPPy/MWNTs modified electrode shows largely enhancing oxidative current responses of DA. When combined with liquid chromatography, it not only obtains a low detection limit of 7.5 x 10(-10) mol L(-1) for DA, but also improves the selectivity of DA detection. Mechanisms for the enhancement are also well discussed in this paper. With this approach, microdialysis has been employed for successful assessment of DA in rat striatum. |
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Authors:
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Jingxia Wen; Li Zhou; Litong Jin; Xuni Cao; Bang-Ce Ye |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-09 |
Journal Detail:
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Title: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Volume: 877 ISSN: 1873-376X ISO Abbreviation: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-15 Completed Date: 2009-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101139554 Medline TA: J Chromatogr B Analyt Technol Biomed Life Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1793-8 Citation Subset: IM |
Affiliation:
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Department of Chemistry, East China Normal University, Shanghai 200062, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biosensing Techniques / methods* Chromatography, Liquid / methods* Corpus Striatum / chemistry Dopamine / analysis* Electrochemical Techniques Electrodes Nanotubes, Carbon / chemistry* Oxidation-Reduction Polymers / chemistry* Pyrroles / chemistry* Rats |
| Chemical | |
Reg. No./Substance:
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0/Nanotubes, Carbon; 0/Polymers; 0/Pyrroles; 30604-81-0/polypyrrole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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