Document Detail


Overgrowth of Enterococcus faecium in the feces of patients with hematologic malignancies.
MedLine Citation:
PMID:  8909828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to characterize the overgrowth and susceptibility of Enterococcus faecium, compared with that of other enterococci, in the feces of patients with hematologic malignancy. During a 52-week period, surveillance samples of feces were cultured weekly. Three hundred thirty-three samples were obtained from 92 patients. E. faecium outnumbered other enterococci in 170 (44%) of the samples, while the opposite was true in 119 (31%) of the samples. Fecal overgrowth of E. faecium (> or = 9.0 log10 cfu/g) was found in 62 samples (16%), while overgrowth of other enterococci was documented in 20 samples (5%) (P < .001). Treatment with third-generation cephalosporins preceded the overgrowth of E. faecium in 93% of the patients. Resistance of E. faecium isolates to ampicillin, high-level gentamicin, and vancomycin was detected in 41%, 4%, and 2% of the patients, respectively. There were 6 patients with enterococcal bacteremia (due to E. faecium in 5 and Enterococcus faecalis in 1) during the study period. The high prevalence of resistance to ampicillin and imipenem rendered few (if any) intravenous antibiotics able to prevent fecal overgrowth of E. faecium.
Authors:
J P Suppola; L Volin; V V Valtonen; M Vaara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  23     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  694-7     Citation Subset:  IM    
Affiliation:
Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Aminoglycosides
Ampicillin Resistance
Anti-Bacterial Agents / therapeutic use
Bacterial Infections / drug therapy*,  microbiology*
Carbapenems / therapeutic use
Cephalosporins / therapeutic use
Colony Count, Microbial
Drug Resistance, Microbial
Enterococcus / growth & development
Enterococcus faecium / drug effects*,  growth & development*
Feces / microbiology*
Hematologic Neoplasms / microbiology*
Humans
Microbial Sensitivity Tests
Nitroimidazoles / therapeutic use
Trimethoprim-Sulfamethoxazole Combination / therapeutic use
Vancomycin / therapeutic use
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Carbapenems; 0/Cephalosporins; 0/Nitroimidazoles; 1404-90-6/Vancomycin; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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