Document Detail

Overexpression of the suppressor of cytokine signalling 3 (SOCS3) in severe atopic dermatitis.
MedLine Citation:
PMID:  16309496     Owner:  NLM     Status:  MEDLINE    
Immunoregulatory conditions in atopic dermatitis (AD) involve both Th1 and Th2, although primarily Th2. The suppressor of cytokine signalling 3 (SOCS3) may mediate Th2 regulatory response through negative regulation of Th1 pathways. We examined SOCS3 expression in skin lesions of patients with severe AD and compared it with that in patients with the Th1 disorder, psoriasis. We assessed SOCS3 expression in skin lesions from seven patients with severe AD and five patients with typical psoriasis, and in skin from three normal subjects, using immunohistochemical staining, in situ hybridization and reverse transcription PCR. Strong SOCS3 expression was found in skin lesions in all patients with AD, but only weak expression in patients with psoriasis and in normal subjects. Overexpression of SOCS3 is prominent in the skin of patients with severe AD and consequently may prove useful for evaluating the severity of AD as a Th2-dominant condition.
Y Horiuchi; S-J Bae; I Katayama
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  31     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-11-28     Completed Date:  2006-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  100-4     Citation Subset:  IM    
Department of Dermatology, Nagasaki University Graduate School of Medicine, Japan.
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MeSH Terms
Dermatitis, Atopic / immunology*
Fibroblasts / immunology
Immunohistochemistry / methods
In Situ Hybridization / methods
Keratinocytes / immunology
Middle Aged
Psoriasis / immunology
Reverse Transcriptase Polymerase Chain Reaction / methods
Skin / immunology,  pathology
Suppressor of Cytokine Signaling Proteins / analysis*
Reg. No./Substance:
0/SOCS3 protein, human; 0/Suppressor of Cytokine Signaling Proteins

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