Document Detail


Overexpression of neuropeptide Y in the dorsomedial hypothalamus increases trial initiation but does not significantly alter concentration-dependent licking to sucrose in a brief-access taste test.
MedLine Citation:
PMID:  23313404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evidence in the literature raises the possibility that alterations in neuropeptide Y (NPY) in the dorsomedial hypothalamus (DMH) may contribute to hyperphagia leading to body weight gain. Previously, we have shown that compared to AAVGFP controls, adeno-associated virus (AAV)-mediated overexpression of NPY in the DMH of lean rats resulted in significantly higher body weight gain that was attributed to increased food intake, and this was further exacerbated by a high-fat diet. Here, we tested AAVNPY and AAVGFP control rats in a brief-access taste procedure (10-s trials, 30-min sessions) to an array of sucrose concentrations under ad libitum and partial food and water access conditions. The test allows for some segregation of the behavioral components by providing a measure of trial initiation (appetitive) and unconditioned licks at each concentration (consummatory). Consistent with previous findings suggesting that NPY has a primary effect on appetitive function, overexpression of DMH NPY did not significantly alter concentration-dependent licking response to sucrose but when tested in a non-restricted food and water schedule, AAVNPY rats initiated significantly more sucrose trials compared to AAVGFP controls in a brief-access taste test.
Authors:
Yada Treesukosol; Sheng Bi; Timothy H Moran
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-10
Journal Detail:
Title:  Physiology & behavior     Volume:  110-111     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-04-01     Completed Date:  2013-09-24     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite / physiology
Conditioning, Operant / drug effects
Consummatory Behavior / drug effects
Data Interpretation, Statistical
Dependovirus / genetics
Dorsomedial Hypothalamic Nucleus / metabolism*
Genetic Vectors
Green Fluorescent Proteins
In Situ Hybridization
Male
Neuropeptide Y / biosynthesis,  genetics,  physiology*
Rats
Rats, Sprague-Dawley
Sucrose
Taste / genetics,  physiology*
Water Deprivation
Grant Support
ID/Acronym/Agency:
DK019302/DK/NIDDK NIH HHS; DK074269/DK/NIDDK NIH HHS; P30 DK079637/DK/NIDDK NIH HHS; R01 DK019302/DK/NIDDK NIH HHS; R01 DK074269/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 147336-22-9/Green Fluorescent Proteins; 57-50-1/Sucrose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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