Document Detail


Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction.
MedLine Citation:
PMID:  12388257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We monitored myocardial function in postinfarcted wild-type (WT) and transgenic (TG) mouse hearts with overexpression of the cardiac Na(+)/Ca(2+) exchanger. Five weeks after infarction, cardiac function was better maintained in TG than WT mice [left ventricular (LV) systolic pressure: WT, 41 +/- 2; TG, 58 +/- 3 mmHg; P < 0.05; maximum rising rate of LV pressure (+dP/dt(max)): WT, 3,750 +/- 346; TG, 5,075 +/- 334 mmHg/s; P < 0.05]. The isometric contractile response to beta-adrenergic stimulation was greater in papillary muscles from TG than WT mice (WT, 13.2 +/- 0.9; TG, 16.3 +/- 1.0 mN/mm(2) at 10(-4) M isoproterenol). The sarcoplasmic reticulum (SR) Ca(2+) content investigated by rapid cooling contractures in papillary muscles was greater in TG than WT mouse hearts. We conclude that myocardial function is better preserved in TG mice 5 wk after infarction, which results from enhanced SR Ca(2+) content via overexpression of the Na(+)/Ca(2+) exchanger.
Authors:
Jiang-Yong Min; Matthew F Sullivan; Xinhua Yan; Xin Feng; Victor Chu; Ju-Feng Wang; Ivo Amende; James P Morgan; Kenneth D Philipson; Thomas G Hampton
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2002-08-08
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  283     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-12     Completed Date:  2002-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H2466-71     Citation Subset:  IM    
Affiliation:
Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology
Animals
Calcium / metabolism
Disease Models, Animal
Disease Progression
Electrocardiography
Gene Expression*
Heart Rate / drug effects,  genetics
Hemodynamics / drug effects,  genetics
Heterozygote
Isoproterenol / pharmacology
Mice
Mice, Transgenic
Myocardial Contraction / drug effects,  genetics
Myocardial Infarction / complications,  physiopathology*
Myocardium / metabolism
Sarcoplasmic Reticulum / metabolism
Sodium-Calcium Exchanger / biosynthesis*,  genetics
Ventricular Dysfunction, Left / complications,  diagnosis,  prevention & control*
Grant Support
ID/Acronym/Agency:
R01 DA-12774/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Sodium-Calcium Exchanger; 7440-70-2/Calcium; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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