Document Detail


Overexpression of erbB-2 protein in gastric adenocarcinoma--a potential role in therapeutic response to adjuvant 5-FU-doxorubicin regimen.
MedLine Citation:
PMID:  1355336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to study the influence of erbB-2 protein overexpression on outcome of patients with gastric cancer after attempted curative resection with or without adjuvant chemotherapy, paraffin embedded sections from 109 cases of primary gastric cancer with defined treatments have been immunostained for erbB-2 protein in a retrospective study. Thirty four cases (31%) showed strong membrane staining of tumor cells. erbB-2 overexpression did not show significant effect on outcome when all patients were considered. However, erbB-2 overexpression was an indicator for poor disease free survival (p = 0.0474), local relapse free survival (p = 0.0293), and overall survival (p = 0.0310) of the patients treated with surgery only (N = 51), while it did not show any effect on outcome of patients treated with 5-FU plus Doxorubicin (FA) as adjuvant chemotherapy (N = 58). Furthermore, the apparent therapeutic benefit from FA regimen was restricted to patients with erbB-2 positive tumors. Combined predictive value of erbB-2 and FA regimen was found to be significant in predicting local relapse in multivariate analysis (p = 0.0439). The data suggests that erbB-2 may be associated with an improved response to FA regimen and that erbB-2 should be included as a potential confounding variable in the analysis of the data from the clinical trials for gastric cancer.
Authors:
J K Roh; S Paik; H C Chung; W Yang; H K Kim; I J Choi; J Kim; E Koh; K S Lee; J S Min
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gan to kagaku ryoho. Cancer & chemotherapy     Volume:  19     ISSN:  0385-0684     ISO Abbreviation:  Gan To Kagaku Ryoho     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-29     Completed Date:  1992-09-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7810034     Medline TA:  Gan To Kagaku Ryoho     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1207-19     Citation Subset:  IM    
Affiliation:
Yonsei Cancer Center Surgery, and Microbiology, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / chemistry*,  mortality,  therapy
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Chemotherapy, Adjuvant
Doxorubicin / administration & dosage
Fluorouracil / administration & dosage
Gastrectomy
Humans
Middle Aged
Predictive Value of Tests
Proto-Oncogene Proteins / analysis*
Receptor, erbB-2
Retrospective Studies
Stomach Neoplasms / chemistry*,  mortality,  therapy
Survival Rate
Tumor Markers, Biological / analysis*
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins; 0/Tumor Markers, Biological; 23214-92-8/Doxorubicin; 51-21-8/Fluorouracil; EC 2.7.10.1/Receptor, erbB-2

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