| Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients. | |
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MedLine Citation:
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PMID: 17657846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To clarify the expression change of Wnt-induced secreted protein-1 (WISP-1) in human rectal cancer and to determine whether it is correlated with invasion and metastasis of human rectal cancer. METHODS: Eighty-six paired samples of rectal cancer and surgically resected distant normal rectal tissue were collected and allocated into cancer group and control group respectively. WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining. RESULTS: WISP-1 gene overexpression was found in 65% (56/86) primary rectal cancers, 2-30 times that of the level in normal matched rectal tissues (P = 0.001). The mRNA expression level was correlated with Duke's staging, histological differentiation grade and lymph node status. The WISP-1 protein expression was in accordance with mRNA expression level. The positive degree of immunohistochemical staining in the cancer group (1.40 +/- 0.35) was different from that in control group (1.04 +/- 0.08, P < 0.001). Moreover, in cancer group the positive staining degree in high-level mRNA cancers (1.46 +/- 0.37, n = 56) was higher than that in low-level mRNA (1.28 +/- 0.28, n = 30, P = 0.018). CONCLUSION: Aberrant levels of WISP-1 expression may play a role in rectal tumorigenesis. WISP-1 may be used as a specific clinical diagnosis and prognosis marker in rectal cancer. |
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Authors:
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Chao Tian; Zong-Guang Zhou; Wen-Jian Meng; Xiao-Feng Sun; Yong-Yang Yu; Li Li; Hong-Zhi Luo; Lie Yang; Bin Zhou; Jun Gu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 13 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-27 Completed Date: 2007-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 3878-82 Citation Subset: IM |
Affiliation:
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Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis,
metabolism*,
pathology Adult Aged Aged, 80 and over Asian Continental Ancestry Group Cell Transformation, Neoplastic / metabolism* Female Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins / metabolism* Male Middle Aged Polymerase Chain Reaction Proto-Oncogene Proteins / metabolism* RNA, Messenger / metabolism Rectal Neoplasms / diagnosis, metabolism*, pathology Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/Proto-Oncogene Proteins; 0/RNA, Messenger; 0/Tumor Markers, Biological; 0/WISP1 protein, human |
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