Document Detail


Overexpression of c-erbB-2 and p21 oncoproteins in human radiation-induced skin ulcers.
MedLine Citation:
PMID:  7473070     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the overexpression of c-erbB-2 and p21 oncoproteins in human radiation-induced skin ulcers using immunohistochemistry. We found that the positive rate of overexpression of c-erbB-2 and p21 oncoproteins was 92.0 and 92.9%, respectively. The overexpression of c-erbB-2 oncoprotein was observed mainly in the cell membrane of squamous epithelial cells and in the cytoplasm of fibroblasts, endothelial cells, leiomyocytes in the media, and in fibrocytes of the adventitia of mesenchymal arterioles. The location of the p21 oncoprotein overexpression was mostly similar to that of c-erbB-2 with stronger staining in the cytoplasm of squamous epithelial cells and weaker staining in mesenchymal arteriolar walls. The overexpression of c-erbB-2 and p21 oncoproteins may be corresponding to the cancer transformation and poor healing of radiation-induced skin ulcers.
Authors:
P Zhao; Z Yang; D W Wang; Y Gao; X Li; G Li
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer     Volume:  14     ISSN:  0731-8898     ISO Abbreviation:  J. Environ. Pathol. Toxicol. Oncol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-12-27     Completed Date:  1995-12-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8501420     Medline TA:  J Environ Pathol Toxicol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-3     Citation Subset:  IM    
Affiliation:
Department of Pathology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Humans
Oncogene Protein p21(ras) / metabolism*
Radiation Injuries / complications,  metabolism*
Receptor, erbB-2 / metabolism*
Skin Ulcer / etiology,  metabolism*
Chemical
Reg. No./Substance:
EC 2.7.10.1/Receptor, erbB-2; EC 3.6.5.2/Oncogene Protein p21(ras)

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