Document Detail

Overexpression of c-Met in cervical intraepithelial neoplasia.
MedLine Citation:
PMID:  23327059     Owner:  NLM     Status:  In-Process    
PURPOSE OF INVESTIGATION: The purpose of this study is to evaluate the significance of the c-Met / Hepatocyte Growth Factor Receptor (HGFR) expression in cervical intraepithelial neoplasia (CIN).
MATERIALS AND METHODS: Twenty-one patients from two types of cervical intraepithelial neoplasias (LSIL and HSIL), diagnosed in our clinic were studied with c-Met immunohistochemistry. Of the 21 cases, five were diagnosed as LSIL and 16 as HSIL. Normal cervical mucosas from five patients were studied with c-Met as control cases.
RESULTS: Overexpression of c-Met was found in all five of LSIL specimens. C-Met overexpression was observed in 11 cases of HSIL. No c-Met overexpression was seen in any of the five control cases.
CONCLUSION: These results revealed that c-Met oncogene overexpression is an important parameter in cervical early oncogenesis and may have a role in malignant transformation of cervical epithelial cells.
C Comunoğlu; K Boynukalin; M G Uğur; R Al; G Mocan Kuzey; C Baykal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  33     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  625-8     Citation Subset:  IM    
Near East University, Faculty of Medicine, Department of Pathology, Nicosia, Turkish Republic of Northern Cyprus, Turkey.
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