| Overexpression of beta-1,4-galactosyltransferase I in rat Schwann cells promotes the growth of co-cultured dorsal root ganglia. | |
MedLine Citation:
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PMID: 12757889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell surface beta-1,4-galactosyltransferase I (beta-1,4-GalT-I) functions as one of the receptors of laminin during the neurite outgrowth on basal lamina by binding to N-linked oligosaccharides in the laminin E8 domain. In this study, we demonstrated that the purified rat Schwann cells transfected with the expression plasmid of beta-1,4-GalT-I cDNA transiently promoted outgrowth and elongation of the neurites from co-cultured rat dorsal root ganglia, while those transfected with the antisense expression plasmid of beta-1,4-GalT-I had the opposite effects. These results suggested that the expression of beta-1,4-GalT-I in Schwann cells of peripheral nerve might promote both growth of developmental neuron and regeneration of injured nerve. |
Authors:
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Aiguo Shen; Jun Yan; Fei Ding; Xiaosong Gu; Dan Zhu; Jianxin Gu |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 342 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-21 Completed Date: 2003-07-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 159-62 Citation Subset: IM |
Affiliation:
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Box 103, Gene Research Center, Shanghai Medical College of Fudan University (Former Shanghai Medical University), 200032, Shanghai, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Blotting, Northern / methods Culture Techniques / methods* DNA, Antisense / metabolism Fetus Ganglia, Spinal / metabolism* Immunohistochemistry / methods N-Acetyllactosamine Synthase / metabolism, physiology* Neurites / physiology* Plasma Rats Rats, Sprague-Dawley Schwann Cells / enzymology*, metabolism Sciatic Nerve Time Factors Transfection / methods |
| Chemical | |
Reg. No./Substance:
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0/DNA, Antisense; EC 2.4.1.90/N-Acetyllactosamine Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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