Document Detail

Overexpression of beta-1,4-galactosyltransferase I in rat Schwann cells promotes the growth of co-cultured dorsal root ganglia.
MedLine Citation:
PMID:  12757889     Owner:  NLM     Status:  MEDLINE    
The cell surface beta-1,4-galactosyltransferase I (beta-1,4-GalT-I) functions as one of the receptors of laminin during the neurite outgrowth on basal lamina by binding to N-linked oligosaccharides in the laminin E8 domain. In this study, we demonstrated that the purified rat Schwann cells transfected with the expression plasmid of beta-1,4-GalT-I cDNA transiently promoted outgrowth and elongation of the neurites from co-cultured rat dorsal root ganglia, while those transfected with the antisense expression plasmid of beta-1,4-GalT-I had the opposite effects. These results suggested that the expression of beta-1,4-GalT-I in Schwann cells of peripheral nerve might promote both growth of developmental neuron and regeneration of injured nerve.
Aiguo Shen; Jun Yan; Fei Ding; Xiaosong Gu; Dan Zhu; Jianxin Gu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  342     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-21     Completed Date:  2003-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Box 103, Gene Research Center, Shanghai Medical College of Fudan University (Former Shanghai Medical University), 200032, Shanghai, People's Republic of China.
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MeSH Terms
Animals, Newborn
Blotting, Northern / methods
Culture Techniques / methods*
DNA, Antisense / metabolism
Ganglia, Spinal / metabolism*
Immunohistochemistry / methods
N-Acetyllactosamine Synthase / metabolism,  physiology*
Neurites / physiology*
Rats, Sprague-Dawley
Schwann Cells / enzymology*,  metabolism
Sciatic Nerve
Time Factors
Transfection / methods
Reg. No./Substance:
0/DNA, Antisense; EC Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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