Document Detail

Overexpression of Id-1 protein is a marker in colorectal cancer progression.
MedLine Citation:
PMID:  18202790     Owner:  NLM     Status:  MEDLINE    
The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an important role in the regulation of cell proliferation and differentiation. We examined the Id-1 expression by immunohistochemistry in 9 adenomas, 79 primary colorectal adenocarcinomas matched with 40 adjacent normal mucosa specimens and its relationship with clinicopathological factors. The Id-1 expression was increased in the carcinoma compared to the adjacent normal mucosa either in the unmatched and matched samples or to the adenoma. There was no significant difference in the Id-1 expression between normal mucosa and adenoma. The Id-1 expression of carcinoma was increased from Dukes' stages A to B, to C and to D. The cases with lymph node metastasis had a higher rate of a stronger Id-1 expression than those without lymph node metastasis. In conclusion, Id-1 overexpression plays an important role in colorectal cancer progression.
Zeng-Ren Zhao; Zhi-Yong Zhang; Hong Zhang; Li Jiang; Ming-Wei Wang; Xiao-Feng Sun
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology reports     Volume:  19     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  419-24     Citation Subset:  IM    
Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China.
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MeSH Terms
Adenoma / etiology,  metabolism,  pathology
Aged, 80 and over
Carcinoma / etiology,  metabolism,  pathology*
Colorectal Neoplasms / etiology,  metabolism,  pathology*
Disease Progression
Inhibitor of Differentiation Protein 1 / analysis,  metabolism*
Lymphatic Metastasis
Middle Aged
Tumor Markers, Biological / analysis,  metabolism*
Reg. No./Substance:
0/ID1 protein, human; 0/Inhibitor of Differentiation Protein 1; 0/Tumor Markers, Biological

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