Document Detail


Overexpression of interleukin-18 aggravates cardiac fibrosis and diastolic dysfunction in fructose-fed rats.
MedLine Citation:
PMID:  20644901     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation plays an important role in the pathophysiology of the metabolic syndrome (MS). We determined whether the overexpression of interleukin (IL)-18 could aggravate left ventricular (LV) remodeling and diastolic dysfunction in fructose-fed rats (FFRs). To create an animal model for MS, male Wistar rats received 10% fructose in water for 8 months. We used an adenovirus encoding rat IL-18 to overexpress IL-18 in FFRs by intravenous administration. IL-18 overexpression led to increases in collagen volume fraction and collagen deposition. LV systolic function was unaltered. But the LV end-diastolic pressure and the time constant of isovolumic relaxation (tau) were increased. Peak negative value of time derivative of LV pressure (-dp/dt) was decreased. Isovolumic relaxation time and myocardial index, as assessed by echocardiography, were increased. Overexpression of IL-18 leads to aggravated LV remodeling and dysfunction in FFRs. Attenuation of the inflammatory process may provide a novel therapeutic strategy in treating metabolic cardiomyopathy.
Authors:
Shan-Shan Xing; Xiu-Ping Bi; Hong-Wei Tan; Yun Zhang; Qi-Chong Xing; Wei Zhang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-12
Journal Detail:
Title:  Molecular medicine (Cambridge, Mass.)     Volume:  16     ISSN:  1528-3658     ISO Abbreviation:  Mol. Med.     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-05     Completed Date:  2011-02-17     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9501023     Medline TA:  Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-70     Citation Subset:  IM    
Affiliation:
Department of Cardiology, QiLu Hospital, Shandong University, Jinan, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / physiopathology*,  ultrasonography
Echocardiography
Fibrosis / metabolism,  physiopathology,  ultrasonography
Fructose / administration & dosage,  metabolism
Heart Failure, Diastolic / physiopathology*,  ultrasonography
Interleukin-18 / metabolism*
Male
Rats
Rats, Wistar
Ventricular Dysfunction, Left / physiopathology*,  ultrasonography
Ventricular Remodeling
Chemical
Reg. No./Substance:
0/Interleukin-18; 30237-26-4/Fructose
Comments/Corrections

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