| Overexpression of DEP domain containing mTOR-interacting protein correlates with poor prognosis in differentiated thyroid carcinoma. | |
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MedLine Citation:
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PMID: 21643629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DEP domain containing mammalian target of rapamycin (mTOR)-interacting protein (DEPTOR), a recently identified mTOR-interacting protein, is a novel candidate oncogene. Previous studies reveal that high DEPTOR expression is required to maintain PI3K and Akt activation and to inhibit apoptosis. However, its significance in differentiated thyroid carcinoma (DTC) is not yet known. The present study verifies the mRNA and protein expression of DEPTOR in five cell lines, DTC tissues and normal adjacent tissues. Tissue microarrays of 114 DTC patients were used to detect DEPTOR protein expression. The assessment of DEPTOR levels demonstrated that DEPTOR in DTC cells and tissues was significantly increased compared with normal cells and adjacent normal tissues. DEPTOR protein expression was significantly associated with lymph node status, extrathyroid extension and distant metastasis. Patients exhibiting high DEPTOR expression were statistically susceptible to earlier recurrence and poorer survival than those with low expression. Univariate and multivariate analyses showed that DEPTOR expression was an independent prognostic factor for DTC recurrence. In conclusion, our data indicate DEPTOR as a novel prognostic marker for DTC. |
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Authors:
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Lei Pei; Pingfang Xie; Enxiang Zhou; Qian Yang; Yi Luo; Zhonghua Tang |
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Publication Detail:
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Type: Journal Article Date: 2011-06-02 |
Journal Detail:
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Title: Molecular medicine reports Volume: 4 ISSN: 1791-3004 ISO Abbreviation: Mol Med Rep Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-07-13 Completed Date: 2011-11-01 Revised Date: 2013-02-22 |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 817-23 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cell Differentiation* Cell Line, Tumor Disease-Free Survival Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Kaplan-Meier Estimate Male Middle Aged Multivariate Analysis Prognosis RNA, Messenger / genetics, metabolism TOR Serine-Threonine Kinases / genetics, metabolism* Thyroid Gland / metabolism, pathology Thyroid Neoplasms / diagnosis*, genetics, pathology* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; EC 2.7.1.1/DEP domain-containing and mTOR-interacting protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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