| Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice. | |
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MedLine Citation:
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PMID: 22170489 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Atopic dermatitis (AD) is a chronically relapsing, noncontagious pruritic skin disease with two phases: acute and chronic. Previous studies have shown that the cysteine protease cathepsin S (CTSS) is linked to inflammatory processes, including atherosclerosis and asthma. The possibility that this or other cysteine proteases might cause itching or be part of a classical ligand-receptor signaling cascade has not been previously considered. Recently, CTSS was shown to be a ligand for proteinase-activated receptor-2 (PAR-2), which is associated with itching. In this study, we show that CTSS-overexpressing transgenic (TG) mice spontaneously develop a skin disorder similar to chronic AD. The results of this study suggest that CTSS overexpression triggers PAR-2 expression in dendritic cells (DCs), resulting in the promotion of CD4(+) differentiation, which is involved in major histocompatibility complex (MHC) class II expression. In addition, we investigated mast cells and macrophages and found significantly higher mean levels of T helper type 1 (Th1) cell-associated cytokines than T helper type 2 (Th2) cell-associated cytokines in CTSS-overexpressing TG mice. These results suggest that increased PAR-2 expression in DCs as a result of CTSS overexpression induces scratching behavior and Th1 cell-associated cytokine expression, and can trigger chronic AD symptoms.Journal of Investigative Dermatology advance online publication, 15 December 2011; doi:10.1038/jid.2011.404. |
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Authors:
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Nari Kim; Ki Beom Bae; Myoung Ok Kim; Dong Hoon Yu; Hei Jung Kim; Hyung Soo Yuh; Young Rae Ji; Si Jun Park; Sol Kim; Kyu-Hee Son; Sang-Joon Park; Duhak Yoon; Dong-Seok Lee; Sanggyu Lee; Hyun-Shik Lee; Tae-Yoon Kim; Zae Young Ryoo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-15 |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: - ISSN: 1523-1747 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Buk-ku, Daegu, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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