| Overexpression of CD9 in Human Breast Cancer Cells Promotes the Development of Bone Metastases. | |
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MedLine Citation:
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PMID: 23225418 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Bone is a preferred target for circulating metastatic breast cancer cells. We found that the CD9 protein was up-regulated in the B02 osteotropic cell line, derived from the aggressive parental MDA-MB-231 breast cancer cell line. Here, we investigated the putative relationship between CD9 expression and the osteotropic phenotype. MATERIALS AND METHODS: Overexpression of CD9 was analyzed by immunoblotting in different cell lines. Immunohistochemistry was used to assess CD9 expression in primary tumors and metastatic lesions. In vivo experiments were conducted in mice using a monoclonal antibody against CD9. RESULTS: CD9 overexpression was confirmed in osteotropic cells. CD9 was significantly overexpressed in bone metastases versus primary tumors and visceral metastatic lesions. Finally, in vivo experiments showed that an antibody against CD9 delays homing of B02 cells in bone marrow, slowing down bone destruction. CONCLUSION: Our study reveals a potential implication of CD9 in the formation of bony metastases from breast cancer cells. |
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Authors:
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Philippe Kischel; Akeila Bellahcene; Blandine Deux; Virginie Lamour; Rowan Dobson; Edwin DE Pauw; Philippe Clezardin; Vincent Castronovo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 32 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 5211-20 Citation Subset: IM |
Affiliation:
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Laboratoire de Physiologie Cellulaire et Moléculaire, Université d'Amiens, UFR des Sciences, 33 Rue Saint-Leu, 80039 Amiens Cedex 1, France. Philippe.Kischel@u-picardie.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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