Document Detail


Overexpression of activated nuclear factor-kappa B in aorta of patients with coronary atherosclerosis.
MedLine Citation:
PMID:  20014193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Inflammation is an established risk factor for atherosclerosis. In an inflammatory state, nuclear factor-kappa B (NF-kappaB) is frequently activated as a key transcription activator for the downstream responses. HYPOTHESIS: The aim of this study was to investigate the changes of NF-kappaB in the aorta of patients with coronary atherosclerosis and its association with atherosclerotic risk factors. METHODS: From 2004 to 2005, we collected a small piece of ascending aorta in the bypass procedure from patients (n = 31) undergoing coronary artery bypass graft (CABG) surgery. The expression of NF-kappaB was determined by immunohistochemistry, and its transcriptional activity was evaluated by electrophoretic mobility shift assay. Celiac aortic tissues from 4 subjects without known atherosclerosis through the kidney donation program were taken as control. RESULTS: NF-kappaB was detectable in aortas from CABG patients with the transcriptional activities significantly increased. The relative level of aortic NF-kappaB expression was elevated in patients who were smokers or with hypertension. Spearman correlation revealed that aortic NF-kappaB expression had significant correlation with coronary severity scores (Gensini score, r = 0.608, P < .05). The NF-kappaB expression was positively correlated with the levels of blood glucose, low-density lipoprotein cholesterol, lipoprotein(a), total cholesterol, and non-high-density lipoprotein cholesterol (P < .05); but negatively correlated with high-density lipoprotein cholesterol (P < .05). CONCLUSIONS: Our study demonstrates a highly activated NF-kappaB in aortas from patients with coronary atherosclerosis, which may reflect overall arterial overinflammatory status. The findings of hyperactive NF-kappaB in aortas may provide a diagnostic parameter for the inflammation that is associated with and may cause atherosclerosis.
Authors:
Wei Zhang; Shan Shan Xing; Xue Lin Sun; Qi Chong Xing
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  32     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E42-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Wiley Periodicals, Inc.
Affiliation:
Shandong University School of Medicine, Jinan, PR China.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aorta / metabolism*,  pathology
Blood Glucose / analysis
Cholesterol / blood
Cholesterol, LDL / blood
Coronary Artery Bypass
Coronary Artery Disease / metabolism*,  surgery
Female
Humans
Hypertension / metabolism
Immunohistochemistry
Lipoprotein(a) / blood
Male
Middle Aged
NF-kappa B / metabolism*
Severity of Illness Index
Smoking / metabolism
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, LDL; 0/Lipoprotein(a); 0/NF-kappa B; 57-88-5/Cholesterol

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