Document Detail

Overdose and safety with fluvoxamine.
MedLine Citation:
PMID:  1806634     Owner:  NLM     Status:  MEDLINE    
The large number of antidepressants available provides a wide range of choice. While clinical effectiveness is the most important consideration, toxicity in overdose must be considered in the risk-benefit assessment of each antidepressant. There are almost 300 deaths each year in Britain from tricyclic overdose, and very few deaths from newer antidepressants. Fluvoxamine appears to have low toxicity in overdose. Symptoms are often minimal: nausea, vomiting, dizziness and somnolence. There is one reported case of prolonged cerebral depression after ingestion of 5.5 g. Overdoses of up to 9 g have produced minimal symptoms and full recovery. No deaths from overdose with fluvoxamine alone have been reported in the literature, although one death certificate in Britain has mentioned fluvoxamine as the cause of death. Fluvoxamine appears to be a valuable alternative to the tricyclic antidepressants, and has a high margin of safety in overdose.
J A Henry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International clinical psychopharmacology     Volume:  6 Suppl 3     ISSN:  0268-1315     ISO Abbreviation:  Int Clin Psychopharmacol     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-05-11     Completed Date:  1992-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8609061     Medline TA:  Int Clin Psychopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-5; discussion 45-7     Citation Subset:  IM    
National Poisons Unit, Guy's Hospital, London, UK.
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MeSH Terms
Dose-Response Relationship, Drug
Fluvoxamine / poisoning*
Middle Aged
Overdose / mortality*
Risk Factors
Reg. No./Substance:

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