Document Detail


Overdose and safety with fluvoxamine.
MedLine Citation:
PMID:  1806634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The large number of antidepressants available provides a wide range of choice. While clinical effectiveness is the most important consideration, toxicity in overdose must be considered in the risk-benefit assessment of each antidepressant. There are almost 300 deaths each year in Britain from tricyclic overdose, and very few deaths from newer antidepressants. Fluvoxamine appears to have low toxicity in overdose. Symptoms are often minimal: nausea, vomiting, dizziness and somnolence. There is one reported case of prolonged cerebral depression after ingestion of 5.5 g. Overdoses of up to 9 g have produced minimal symptoms and full recovery. No deaths from overdose with fluvoxamine alone have been reported in the literature, although one death certificate in Britain has mentioned fluvoxamine as the cause of death. Fluvoxamine appears to be a valuable alternative to the tricyclic antidepressants, and has a high margin of safety in overdose.
Authors:
J A Henry
Related Documents :
23039064 - The use of cluster and principal component analysis in the estimation of iron status in...
14523884 - 70-mph speed limit and motor vehicular fatalities on interstate highways.
23639744 - Histological chorioamnionitis: effects on premature delivery and neonatal prognosis.
23705084 - Cerebellar herniation after lumbar puncture in galactosemic newborn.
21629154 - The influence of maternal body mass index on infant adiposity and hepatic lipid content.
18469364 - Detection of ige anti-parvovirus antibodies in human breast milk.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International clinical psychopharmacology     Volume:  6 Suppl 3     ISSN:  0268-1315     ISO Abbreviation:  Int Clin Psychopharmacol     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-05-11     Completed Date:  1992-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8609061     Medline TA:  Int Clin Psychopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-5; discussion 45-7     Citation Subset:  IM    
Affiliation:
National Poisons Unit, Guy's Hospital, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Dose-Response Relationship, Drug
Female
Fluvoxamine / poisoning*
Humans
Male
Middle Aged
Overdose / mortality*
Risk Factors
Chemical
Reg. No./Substance:
54739-18-3/Fluvoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The elderly depressed and treatment with fluvoxamine.
Next Document:  Obsessive-compulsive disorder.