Document Detail

Overdiagnosis of bladder carcinoma.
MedLine Citation:
PMID:  18980157     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe a group of archival patients who were overdiagnosed with bladder cancer according to contemporary criteria.
STUDY DESIGN: The study group consisted of 27 over-diagnosed patients who were identified upon review of a consecutive series of well-differentiated urothelial carcinomas (grade 1 transitional cell carcinoma) diagnosed between 1958 and 1963.
RESULTS: The mean patient age was 61 years (range, 34-83). Findings overdiagnosed as malignancy included urothelial papilloma (9 patients), inverted papilloma (5), exuberant von Brunn's nest proliferation (hyperplasia) (5), papillary and polypoid cystitis (4), papillary urothelial hyperplasia (2), squamous papilloma (1) and endocervicosis (1). None were treated. During a mean followup of 12.2 years, 1 patient developed carcinoma in situ 11 years after diagnosis, and 1 was diagnosed with noninvasive low-grade urothelial carcinoma 5 years after diagnosis.
CONCLUSION: The most frequent mimics of malignancy were urothelial papilloma, inverted papilloma, von Brunn nest hyperplasia and papillary polypoid cystitis. Awareness of these cancer mimics is critical to avoid overdiagnosis of bladder cancer.
Liang Cheng; David G Bostwick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology     Volume:  30     ISSN:  0884-6812     ISO Abbreviation:  Anal. Quant. Cytol. Histol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-04     Completed Date:  2008-11-26     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  8506819     Medline TA:  Anal Quant Cytol Histol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-4     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Carcinoma, Transitional Cell / diagnosis*
Cystitis / diagnosis*
Diagnostic Errors*
Middle Aged
Papilloma / diagnosis*
Retrospective Studies
Urinary Bladder Neoplasms / diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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