| Overcoming therapeutic inertia in patients with hypertension. | |
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MedLine Citation:
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PMID: 20107295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uncontrolled blood pressure (BP) remains a leading contributor to cardiovascular disease and mortality worldwide. Although current practice guidelines recommend treating patients with hypertension to defined BP goals, the approach is not widely implemented, and BP control in clinical practice is much worse than that attained in clinical trials. Recent and ongoing clinical trials are utilizing more aggressive approaches with combination therapy as initial treatment. This article discusses the problem of therapeutic or clinical inertia when attempting to control hypertension and highlights differences in BP control rates between clinical trials and real-world practice. Additionally, the rationale for an ongoing treat-to-goal study using a fixed-dose combination of amlodipine/olmesartan medoxomil in patients with hypertension not controlled on monotherapy is provided. |
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Authors:
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Shawna D Nesbitt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Postgraduate medicine Volume: 122 ISSN: 1941-9260 ISO Abbreviation: Postgrad Med Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-28 Completed Date: 2010-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401147 Medline TA: Postgrad Med Country: United States |
Other Details:
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Languages: eng Pagination: 118-24 Citation Subset: AIM; IM |
Affiliation:
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Internal Medicine-Hypertension, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8586, USA. shawna.nesbitt@utsouthwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Blood Pressure / drug effects Cardiovascular Diseases / etiology Drug Therapy, Combination Humans Hypertension / complications, drug therapy* Medication Adherence* Physician's Practice Patterns* Practice Guidelines as Topic Treatment Failure Treatment Refusal* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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