Document Detail

Overcoming the chromatin barrier to end resection.
MedLine Citation:
PMID:  23147792     Owner:  NLM     Status:  MEDLINE    
Repair of double-strand breaks by homologous recombination requires Repair of double-strand breaks by homologous recombination requires 5'-3' resection of the DNA ends to create 3' single-stranded DNA tails. While much progress has been made in identifying the proteins that directly participate in end resection, how this process occurs in the context of chromatin is not well understood. Two papers in Nature report that Fun30, a poorly characterized member of the Swi2/Snf2 family of chromatin remodelers, plays a role in end processing by facilitating the Exo1 and Sgs1-Dna2 resection pathways.
Huan Chen; Lorraine S Symington
Publication Detail:
Type:  Journal Article     Date:  2012-11-13
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-05     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  317-9     Citation Subset:  IM    
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MeSH Terms
Chromatin / genetics,  metabolism*
DNA Breaks, Double-Stranded
DNA Helicases / genetics,  metabolism
DNA Repair / genetics,  physiology
DNA, Single-Stranded / genetics,  physiology
Exodeoxyribonucleases / genetics,  metabolism
RecQ Helicases / genetics,  metabolism
Saccharomyces cerevisiae Proteins / genetics,  metabolism*
Transcription Factors / genetics,  metabolism
Reg. No./Substance:
0/Chromatin; 0/DNA, Single-Stranded; 0/FUN30 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; 0/Transcription Factors; EC 3.1.-/Exodeoxyribonucleases; EC I; EC 3.6.1.-/SGS1 protein, S cerevisiae; EC 3.6.4.-/DNA Helicases; EC protein, S cerevisiae; EC Helicases

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