| Overcoming MDR by ultrasound-induced hyperthermia and P-glycoprotein modulation. | |
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MedLine Citation:
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PMID: 11708777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed the effects of combining ultrasound-induced hyperthermia (USHT) with the P-glycoprotein modulator PSC 833 on cellular retention and cytotoxicity of rhodamine 123 (R123) and doxorubicin in the parent and multidrug resistance (MDR) variants of two human cancer lines. USHT significantly increased cellular uptake of R123 and doxorubicin. Without PSC 833, release of R123 and doxorubicin from both USHT-treated and untreated cells was rapid. As expected, PSC 833 (0.5 microM) only slowed their release into the MDR lines. Interestingly, despite the differences in their starting amounts, PSC 833 was effective in prolonging R123 and doxorubicin release from both USHT-treated and untreated MDR cells. PSC 833 did not augment the cytotoxicity of doxorubicin in parent lines but did cause a significant increase in cytotoxicity of doxorubicin in the MDR lines. However, the combined effect of USHT and PSC 833 on cytotoxicity of doxorubicin far exceeded that produced by USHT or PSC 833 alone. |
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Authors:
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Y Liu; K Lillehei; W N Cobb; U Christians; K Y Ng |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 289 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-15 Completed Date: 2001-12-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 62-8 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Academic Press. |
Affiliation:
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Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacokinetics,
pharmacology Biological Transport, Active / drug effects Cell Division / drug effects Cell Survival / drug effects Cyclosporins / pharmacology Doxorubicin / pharmacokinetics, pharmacology Drug Resistance, Multiple* Hot Temperature* Humans P-Glycoprotein / metabolism* Rhodamine 123 / pharmacokinetics Tumor Cells, Cultured Ultrasonics |
| Grant Support | |
ID/Acronym/Agency:
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CA78788/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Cyclosporins; 0/P-Glycoprotein; 121584-18-7/valspodar; 23214-92-8/Doxorubicin; 62669-70-9/Rhodamine 123 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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