Document Detail

Overcoming MDR by ultrasound-induced hyperthermia and P-glycoprotein modulation.
MedLine Citation:
PMID:  11708777     Owner:  NLM     Status:  MEDLINE    
We assessed the effects of combining ultrasound-induced hyperthermia (USHT) with the P-glycoprotein modulator PSC 833 on cellular retention and cytotoxicity of rhodamine 123 (R123) and doxorubicin in the parent and multidrug resistance (MDR) variants of two human cancer lines. USHT significantly increased cellular uptake of R123 and doxorubicin. Without PSC 833, release of R123 and doxorubicin from both USHT-treated and untreated cells was rapid. As expected, PSC 833 (0.5 microM) only slowed their release into the MDR lines. Interestingly, despite the differences in their starting amounts, PSC 833 was effective in prolonging R123 and doxorubicin release from both USHT-treated and untreated MDR cells. PSC 833 did not augment the cytotoxicity of doxorubicin in parent lines but did cause a significant increase in cytotoxicity of doxorubicin in the MDR lines. However, the combined effect of USHT and PSC 833 on cytotoxicity of doxorubicin far exceeded that produced by USHT or PSC 833 alone.
Y Liu; K Lillehei; W N Cobb; U Christians; K Y Ng
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  289     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-15     Completed Date:  2001-12-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
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MeSH Terms
Antineoplastic Agents / pharmacokinetics,  pharmacology
Biological Transport, Active / drug effects
Cell Division / drug effects
Cell Survival / drug effects
Cyclosporins / pharmacology
Doxorubicin / pharmacokinetics,  pharmacology
Drug Resistance, Multiple*
Hot Temperature*
P-Glycoprotein / metabolism*
Rhodamine 123 / pharmacokinetics
Tumor Cells, Cultured
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents; 0/Cyclosporins; 0/P-Glycoprotein; 121584-18-7/valspodar; 23214-92-8/Doxorubicin; 62669-70-9/Rhodamine 123

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