Document Detail

Overall renal and tubular function during infusion of amino acids in normal man.
MedLine Citation:
PMID:  2162277     Owner:  NLM     Status:  MEDLINE    
1. Amino acids have been used to test renal reserve filtration capacity. Previous studies suggest that amino acids increase glomerular filtration rate (GFR) by reducing distal tubular flow and tubuloglomerular feedback activity. 2. Glomerular function and the renal tubular handling of sodium during infusion of amino acids was studied in 12 normal volunteers. 3. Clearance of sodium (CNa) was unchanged. Effective renal plasma flow increased slightly, but significantly, by 9% (P less than 0.05). GFR was increased by 13% (P less than 0.001). Clearance of lithium (CLi) (used as an index of proximal tubular outflow) increased by 38% (P less than 0.001). Calculated absolute proximal reabsorption (GFR-CLi) remained unchanged. Fractional proximal reabsorption [1-(CLi/GFR)] was decreased by 10% (P less than 0.001). Calculated absolute distal sodium reabsorption [(CLi-CNa) x PNa, where PNa is plasma sodium concentration] increased by 40% (P less than 0.001). Plasma renin concentration did not change significantly. 4. The results suggest that amino acids increase GFR by a primary effect on renal haemodynamics or, less likely, by reducing the signal to the tubuloglomerular feedback mechanism. The increase in proximal tubular outflow was compensated for in the distal tubules, so that the sodium excretion rate remained unchanged.
N V Olsen; J M Hansen; S D Ladefoged; N Fogh-Andersen; S L Nielsen; P P Leyssac
Related Documents :
19566467 - Effects of meloxicam on plasma iohexol clearance as a marker of glomerular filtration r...
9134637 - Pharmacokinetics of recombinant hirudin in hemodialyzed end-stage renal failure patients.
3731917 - Pharmacokinetics of metronidazole and its metabolites in reduced renal function.
237647 - Polymorphic acetylation procainamide in man.
1262437 - Adrenocortical response to marathon running.
20713347 - Reduction of false-negative results in inferior petrosal sinus sampling with simultaneo...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  78     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-24     Completed Date:  1990-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  497-501     Citation Subset:  IM    
Department of Nephrology, Herlev Hospital, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acids / pharmacokinetics*
Glomerular Filtration Rate / physiology
Kidney / metabolism*
Kidney Tubules / metabolism
Lithium / pharmacokinetics
Middle Aged
Osmolar Concentration
Renal Circulation
Sodium / urine
Reg. No./Substance:
0/Amino Acids; 7439-93-2/Lithium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relationship between inspiratory drive and perceived inspiratory effort in normal man.
Next Document:  Renal tubular reabsorption of sodium and water during infusion of low-dose dopamine in normal man.