Document Detail

Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging.
MedLine Citation:
PMID:  12807408     Owner:  NLM     Status:  MEDLINE    
The anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been found to be hyperactive at rest, during symptom provocation, and after commission of errors in cognitive tasks. This hyperactivity might reflect an abnormality in conflict detection, a hypothesized basic mechanism for the action-monitoring function of the ACC. This hypothesis was tested using functional magnetic resonance imaging, by scanning 11 OCD patients and 13 matched control subjects while they performed a version of the continuous-performance task with four trial types that induced graded levels of response conflict. Although a behavioral index of conflict (i.e., accuracy) was similar for patients and control subjects, the ACC activation was increased in patients during high-conflict trials. The error-related activity in the same brain region was also higher in patients, consistent with previous electrophysiological findings. Both conflict- and error-related activity showed trends for positive correlations with severity of OCD symptoms, but not with anxiety. These findings suggest that as part of an overactive action-monitoring system, the ACC is more directly involved in the pathophysiology of OCD than previously thought.
Stefan Ursu; V Andrew Stenger; M Katherine Shear; Mark R Jones; Cameron S Carter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychological science     Volume:  14     ISSN:  0956-7976     ISO Abbreviation:  Psychol Sci     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-16     Completed Date:  2003-09-29     Revised Date:  2011-05-20    
Medline Journal Info:
Nlm Unique ID:  9007542     Medline TA:  Psychol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347-53     Citation Subset:  IM    
Department of Neuroscience, University of Pittsburgh, USA.
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MeSH Terms
Arousal / physiology
Attention / physiology*
Brain Mapping
Cognitive Dissonance
Gyrus Cinguli / physiopathology*
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Magnetic Resonance Imaging*
Middle Aged
Obsessive-Compulsive Disorder / diagnosis,  physiopathology*
Oxygen Consumption / physiology
Psychomotor Performance / physiology
Reaction Time / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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