Document Detail

Ovarian stromal hypertrophy in polycystic ovary syndrome.
MedLine Citation:
PMID:  9800673     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the relationship between the ovarian stromal area and clinical hormonal characteristics in women with polycystic ovary syndrome (PCOS). STUDY DESIGN: Twenty-eight women with PCOS (group 1) and 26 healthy women (group 2) participated in this study. For measuring the ovarian stromal area, transvaginal ultrasonography was performed on all women during the early follicular phase of the menstrual cycle. Venous blood was sampled from the women to determine serum follicle stimulating hormone, luteinizing hormone (LH), estradiol, androstenedione, free testosterone (FT), total testosterone (TT), 17 alpha-hydroxyprogesterone, dehydroepiandrosterone sulfate, and fasting insulin and glucose levels. Two-tailed t and Pearson correlation tests were used for statistical analysis. RESULTS: Women with PCOS were heavier, and their serum FT, TT and LH levels were significantly higher than in the normals (P < .001, P < .012 and P < .001, respectively). The ovarian stromal area measured by transvaginal ultrasonography was also significantly larger than in the normals (P < .001). Only basal serum insulin levels seemed to correlate positively with the ovarian stromal area in women with PCOS (r = .43 P = .09). CONCLUSION: Although transvaginal ultrasonography has played an important role in the evaluation of women with PCOS, we could not demonstrate a relationship between the ovarian stromal area and hormonal characteristics of PCOS. Therefore, transvaginal ultrasonography and hormonal parameters must be used as complementary diagnostic methods in women with PCOS.
S Kaleli; C T Erel; E Oral; K Elter; C Akman; U Colgar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  43     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-26     Completed Date:  1999-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  893-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Turkey.
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MeSH Terms
Body Weight
Gonadal Steroid Hormones / blood
Insulin / blood
Ovary / pathology*,  physiology
Polycystic Ovary Syndrome / pathology*
Stromal Cells / pathology,  physiology
Reg. No./Substance:
0/Gonadal Steroid Hormones; 11061-68-0/Insulin

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