Document Detail


Ovarian stimulation and the risk of aneuploid conceptions.
MedLine Citation:
PMID:  20828683     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To examine the rate of aneuploidy in missed abortions in patients who conceived after FSH ovarian stimulation compared with women who conceived in a natural cycle.
DESIGN: Retrospective cohort.
SETTING: Academic reproductive endocrinology and infertility center.
PATIENT(S): Women with karyotyping of products of conception (POC) from a missed abortion from January 1999 through August 2007. The rate of aneuploidy was compared between patients with a history of infertility who conceived naturally and patients with a history of infertility who conceived with FSH treatment.
INTERVENTION(S): Ovarian stimulation with FSH, intrauterine insemination, and in vitro fertilitzation; genetic testing of POC after dilation and curettage.
MAIN OUTCOME MEASURE(S): Embryonic karyotype.
RESULT(S): A total of 229 pregnancies met inclusion criteria, and of these, 64% had an abnormal karyotype. The rate of aneuploidy was 63% in the study group and 70% in the control group. This difference was not statistically significant.
CONCLUSION(S): The incidence of embryonic aneuploidy was not higher in pregnancies conceived with FSH stimulation compared with spontaneous conceptions in infertility patients. This suggests that exogenous FSH exposure does not increase the risk of aneuploidy.
Authors:
Jamie A M Massie; Lora K Shahine; Amin A Milki; Lynn M Westphal; Ruth B Lathi
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Publication Detail:
Type:  Journal Article     Date:  2010-09-15
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  970-2     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Stanford Fertility and Reproductive Medicine Center, Palo Alto, California.
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