Document Detail

Ovarian stimulation protocols based on follicle-stimulating hormone glycosylation pattern: impact on oocyte quality and clinical outcome.
MedLine Citation:
PMID:  19939369     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the impact of follicle-stimulating hormone (FSH) with different glycosylation patterns on oocyte quality and clinical outcomes in an in vitro fertilization (IVF) treatment program. DESIGN: Prospective randomized, open-label, clinical study. SETTING: Assisted reproduction center. PATIENT(S): One hundred eighty-eight infertile couples undergoing assisted fertilization treatment. INTERVENTION(S): All participants underwent a standard down-regulation with a gonadotropin-releasing hormone (GnRH) analogue. The patients were randomized into three groups: 63 patients received combined sequential acidic and less-acidic FSH, 65 patients received only less-acidic FSH (recombinant FSH), and 60 received only acidic FSH (human-derived FSH). MAIN OUTCOME MEASURE(S): Number of mature metaphase II oocytes, embryo quality, clinical pregnancy rates, and implantation rates. RESULT(S): The pregnancy and implantation rates were statistically significantly lower in the less-acidic recombinant FSH alone group than in the combined sequential acidic hFSH/less-acidic recombinant FSH, and acidic hFSH alone groups (33.3%, 43.5%, 39% and 17.3%, 24.5%, 20.4%, respectively). Metaphase II oocytes and grade 1 embryos were statistically significantly higher in favor of the combined sequential acidic hFSH/less-acidic recombinant FSH group compared with the less-acidic recombinant FSH alone group. CONCLUSION(S): The glycosylation patterns of the two types of FSH implemented for ovarian stimulation have different impacts on oocyte quality and clinical outcome. A sequential combined protocol using both acidic and less-acidic FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.
Helmy Selman; Arianna Pacchiarotti; Imam El-Danasouri
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-11-25
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1782-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Praxi Provita, Rome, Italy.
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MeSH Terms
Embryo Transfer / methods
Fertilization in Vitro / methods
Follicle Stimulating Hormone / metabolism,  pharmacology*
Oocytes / drug effects*,  physiology*
Ovarian Follicle / drug effects,  physiology
Ovulation Induction / methods*
Pregnancy Rate*
Prospective Studies
Reg. No./Substance:
9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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