Document Detail


Ovarian stimulation and intrauterine insemination in women aged 40years or more.
MedLine Citation:
PMID:  22197126     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fertility decreases with advancing age. This study retrospectively reviewed the results of ovarian stimulation and intrauterine insemination (IUI) in women ⩾40years old with diminished ovarian reserve or unexplained infertility who underwent treatment with ovarian stimulation/IUI with clomiphene citrate or gonadotrophin and compared them with the results of IVF and in-vitro maturation (IVM) treatments. The main outcome measures were pregnancy and live-birth rates. The profiles of the patients in ovarian stimulation, IVM and IVF groups were comparable. There were no clinical pregnancies in the clomiphene citrate and IVM groups. The clinical-pregnancy rates in the gonadotrophin and IVF groups were 2.6% and 16.9% and the live-birth rates were 2.6% and 13.7%, respectively. Compared with ovarian stimulation, IVF is most effective for women aged 40years or more. Attempting success with ovarian stimulation or IVM will delay conception unnecessarily. Fertility decreases with advancing age. The purpose of our study was to retrospectively review the results of ovarian stimulation and intrauterine insemination (IUI) in women aged ⩾40years with diminished ovarian reserve or unexplained infertility who underwent treatment with ovarian stimulation/IUI with clomiphene citrate or gonadotrophin and to compare them with those of IVF and in-vitro maturation (IVM) treatments. The main outcome measures were pregnancy and live-birth rates. The profiles of the patients in the ovarian stimulation, IVM and IVF were comparable. There were no clinical pregnancies in the clomiphene citrate and IVM groups. The clinical pregnancy in the gonadotrophin and IVF groups were 2.6% and 16.9% and the live-birth rates were 2.6% and 13.7%, respectively. Compared with ovarian stimulation, IVF is the most effective treatment for women aged ⩾40years. Attempting success with ovarian stimulation or IVM will delay conception unnecessarily.
Authors:
Amir Wiser; Einat Shalom-Paz; Shauna Leigh Reinblatt; Weon-Young Son; Mausumi Das; Togas Tulandi; Hananel Holzer
Related Documents :
8608796 - Ucb l059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat ...
17400456 - Changing australian prescribing patterns for antiepileptic drugs in pregnancy and their...
23219036 - Rapid calculation of standardized placental volume at 11 to 13 weeks and the predictio...
22506316 - Pregnancy outcome of monochorionic twins: does amnionicity matter?
2771556 - Prenatal exposure to alcohol: effect on infant growth and morphologic characteristics.
15992686 - Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of bioti...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-20
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  -     ISSN:  1472-6491     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Predictive value of Spanish neuropsychological testing for laterality in patients with epilepsy.
Next Document:  Follicular and endocrine profiles associated with different GnRH-antagonist regimens: a randomized c...