Document Detail

Ovarian steroid synthesis in tissue culture after administration of hormones and epidermal growth factor
MedLine Citation:
PMID:  1905128     Owner:  NLM     Status:  MEDLINE    
The features of steroidogenesis of immature mouse ovaries in culture under the influence of follicle-stimulating hormones (FSH), human chorionic gonadotropin (hCG), epidermal growth factor (EGF) and insulin have been investigated during the period of reinitiation of meiosis in the oocytes. Secretion of progesterone is stimulated after addition of FSH, hCG and of insulin and EGF combination to the medium. EGF increases FSH-stimulated progesterone secretion and inhibits estradiol secretion. The ratios progesterone/estradiol and testosterone/estradiol increase, when EGF is added to the culture medium. It is analogous to the action of hCG. It is suggested that EGF may be an intrafollicular EGF regulator of luteinizing hormone action on the sex and somatic cells of the mammalian ovaries.
O A Vorob'eva; F A Svechnikova; A I Nikitin; V V Potin
Publication Detail:
Type:  Comparative Study; English Abstract; In Vitro; Journal Article    
Journal Detail:
Title:  Arkhiv anatomii, gistologii i émbriologii     Volume:  100     ISSN:  0004-1947     ISO Abbreviation:  Arkh Anat Gistol Embriol     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-07-25     Completed Date:  1991-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370603     Medline TA:  Arkh Anat Gistol Embriol     Country:  USSR    
Other Details:
Languages:  rus     Pagination:  78-82     Citation Subset:  IM    
Vernacular Title:
Steroidogenez iaichnikov v kul'ture pri deĭstvii gormonov i epidermal'nogo faktora rosta.
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MeSH Terms
Chorionic Gonadotropin / pharmacology*
Drug Interactions
Epidermal Growth Factor / pharmacology*
Estradiol / biosynthesis*
Follicle Stimulating Hormone / pharmacology*
Ovary / drug effects,  metabolism*
Progesterone / biosynthesis*
Testosterone / biosynthesis*
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol; 57-83-0/Progesterone; 58-22-0/Testosterone; 62229-50-9/Epidermal Growth Factor; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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